research Staining of Human Skin With RGB Trichrome Unveils a Proteoglycan-Enriched Zone in the Hair Dermal Sheath
A new staining method shows a special area in the hair's skin layer with lots of proteoglycans.
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research Oncogenic Kras Induces Spatiotemporally Specific Tissue Deformation Through Converting Pulsatile Into Sustained ERK Activation
The Kras mutation changes normal cell signals, leading to disrupted tissue structure and potential cancer.
research Mediator 1 Ablation Induces Enamel-to-Hair Lineage Conversion Through Enhancer Dynamics
Removing Mediator 1 causes teeth cells to turn into hair cells.
research Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle
Changing the structure of the hair follicle's environment can affect hair quality but doesn't stop hair growth.
research Medication Clusters at Hospital Discharge and Risk of Adverse Drug Events at 30-Days Post-Discharge: A Population-Based Cohort Study of Older Adults
Certain groups of medications given when leaving the hospital are linked to a higher risk of negative drug reactions within 30 days, especially in older adults with respiratory issues.
research Developing Patient-Reported Outcome Measure for Hair and Skin Disorders
The goal is to create a tool for patients to report their experiences with various hair and scalp disorders.
research Autoimmunity in Satoyoshi Disease: A Systematic Review
Satoyoshi syndrome is likely an autoimmune disease that mainly affects young women and improves with immune-related treatments.
research An ERK-Dependent Molecular Switch Antagonizes Fibrosis And Promotes Regeneration In Spiny Mice (Acomys)
A specific molecular switch, driven by MAPK/ERK signaling, helps spiny mice heal wounds by regenerating skin instead of forming scars.
research Involvement of ILC1-Like Innate Lymphocytes in Human Autoimmunity: Lessons from Alopecia Areata
ILC1-like cells can cause alopecia areata by attacking hair follicles.
research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization
The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
research Blood Group O and Post-COVID-19 Syndrome
People with blood group O may have a higher risk of developing post-COVID-19 syndrome.
research Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome
Skin lesions in Carney complex are likely caused by a specific group of skin cells that promote pigment production due to a genetic mutation.
research Signaling Modality Within GP130 Receptor Enhances Tissue Regeneration
The gp130 receptor helps in tissue regeneration and disease progression, and manipulating it could improve healing and prevent disease.
research 4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression
4-aminopyridine helps skin wounds heal faster and better.
research Non-Canonical Wnt Signaling Promotes Directed Migration of Intestinal Stem Cells to Sites of Injury
Special gut cells help stem cells move to and fix injured areas by activating a specific signaling pathway.
research New Intranasal and Injectable Gene Therapy for Healthy Life Extension
Gene therapy in mice increased lifespan and improved health without causing cancer.
research Tfap2b Specifies an Embryonic Melanocyte Stem Cell That Retains Adult Multi-Fate Potential
The gene Tfap2b is essential for creating a type of stem cell in zebrafish that can become different pigment cells.
research KIF18B Is a Cell-Type Specific Regulator of Spindle Orientation in the Epidermis
KIF18B is important for correctly positioning cell division machinery in skin cells, affecting hair follicle development.
research Deletion of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2 in FoxD1-Lineage Mesenchymal Cells Leads to Congenital Truncal Alopecia
Removing a specific gene in certain skin cells causes hair loss on the body by disrupting normal hair development.
research The Alopecia Areata Phenotype Is Induced by the Water Avoidance Stress Test in CCHCR1-Deficient Mice
Stress can cause a type of hair loss in mice lacking the CCHCR1 gene.
research Glutamic Acid Promotes Hair Growth in Mice
Glutamic acid helps mice grow hair.
research Crystal Structure of Steroid Reductase SRD5A Reveals Conserved Steroid Reduction Mechanism
The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.
research Neutrophil Extracellular Traps Impair Regeneration
Neutrophil extracellular traps slow down hair follicle healing after injury.
research Stabilization of Beta-Catenin Promotes Melanocyte Specification at the Expense of the Schwann Cell Lineage
Activating β-catenin increases melanocytes and decreases Schwann cells.
research Lef1 Expression in Fibroblasts Maintains Developmental Potential in Adult Skin to Regenerate Wounds
Lef1 helps adult skin cells maintain their ability to heal wounds and regenerate hair, but the study's methods and conclusions have been questioned.
research Specific Ectodermal Enhancers Control the Expression of Hoxc Genes in Developing Mammalian Integuments
The HoxC gene cluster and its enhancers are essential for developing hair and nails in mammals.
research Health Benefits Attributed to 17α-Estradiol, a Lifespan-Extending Compound, Are Mediated Through Estrogen Receptor α
17α-estradiol extends lifespan and improves metabolism in male mice through the estrogen receptor α.
research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)
The study found that certain genes are important for hedgehog skin appendage development and immunity, with spines possibly evolving for protection and infection resistance.
research Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development
Skin healing from blisters can delay hair growth as stem cells focus on repairing skin over developing hair.
research No Relationship Between Perceived Health Anomalies and Perceived Experimental Success in Retired Breeder Male Hartley Albino Guinea Pigs
Health issues in retired breeder guinea pigs don't affect experiment success.