January 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers observed that after mesenchymal cell division in mouse and chicken embryonic skin, elevated migration speed and persistence for 180 minutes contribute to mesenchymal dispersal and preferential recruitment to dermal condensates.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inducing miR-205 reduces actin contractility and stiffness in hair follicle stem cells and progenitors, stimulating hair regeneration in both young and old mice.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reported that an injectable hydrogel microparticle vaccine platform enhanced antibody responses and protection against influenza in mice, outperforming the traditional adjuvant aluminum hydroxide.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, deep learning models accurately predicted gene expression in whole slide images of colorectal cancer, with convolutional neural networks outperforming transformer and graph-based approaches in spatial RNA pattern prediction.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that conditional deletion of Mof in mice resulted in severe defects in skin development, including compromised epidermal differentiation and hair growth, leading to perinatal lethality.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that prostaglandin E2 pretreatment may reduce radiotherapy-induced alopecia by enhancing hair follicle self-repair through transient G1 arrest, suggesting a potential preventive treatment.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers mapped gene expression in developing hair follicles to reveal unknown cell populations and markers, suggesting early establishment of cell fates in hair placodes.
November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers observed that blood vessel maturation in mice involves neonatal endothelial cells expanding the capillary network through vessel regression and angiogenesis, with adult cells later maintaining stability and repair through specific signaling pathways.
October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that Sox9, Caveolin1, and Androgen receptor genes are expressed in both skin tissues and musk glands of Chinese forest musk deer, suggesting their importance in these tissues.
October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that fly blood progenitors in a long-term organ culture model undergo symmetric cell divisions influenced by cell size and orientation, with infection triggering changes in cell differentiation kinetics.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies gene-regulatory networks related to genetic variants in skin and hair diseases, suggesting that dermal papilla cells are crucial in androgenetic alopecia.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study indicates that a helminth-derived protein, TGF-β mimic, may accelerate wound healing and promote regenerative processes in skin tissue by interacting with TGF-β receptors.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study applied a new RGB trichrome stain to human skin samples, revealing distinct structural staining in normal tissues and potential proteoglycan-rich zones in hair follicles.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers using live mice observed that oncogenic Kras mutation disrupts hair follicle architecture by sustaining ERK signal activation, which affects stem cell behavior and tissue integrity.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the deletion of Med1 in dental epithelia causes a shift from dental to hair tissue development, suggesting the importance of Med1 in maintaining tissue-specific lineage.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that while niche architecture optimizes organ efficiency during hair follicle growth, it is not essential for the function of stem cell-derived tissues.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that hair follicles and urine cell pellets from noninvasive samples may be the most promising for transcriptomic analyses due to their consistent quality and applicability to disease-relevant research.
August 2022 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that certain medication clusters prescribed at hospital discharge are associated with different risks of adverse drug events in older adults, with respiratory cluster patients facing the highest risk.
August 2022 in “medRxiv (Cold Spring Harbor Laboratory)” This protocol outlines a study aiming to develop a universal patient-reported outcome measure for various hair disorders through qualitative interviews, with no new clinical results reported yet.
August 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that in mice, competition for hair follicles guides the organization of follicle-innervating LTMR neurons during early development, with different neuronal subtypes showing varying adaptive responses to increased neuron populations.
July 2022 in “medRxiv (Cold Spring Harbor Laboratory)” This review supports an autoimmune hypothesis for Satoyoshi syndrome, noting associations with autoantibodies and autoimmune diseases, and reports an observed improvement in most patients with corticosteroid or immunosuppressant treatments.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that MAPK/ERK signaling plays a key role in driving tissue regeneration in spiny mice and suggests potential for reversing fibrosis to promote regeneration in mammals.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study provides evidence that innate lymphoid cells-type 1 can induce alopecia areata in human hair follicles, challenging the view that it is solely a CD8+ T cell-driven autoimmune disease.
June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that anabolic steroid use combined with plakoglobin deficiency caused pathological atrial electrical remodeling in young male mice, suggesting a higher risk of atrial myopathy for males with desmosomal gene variants.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that intracrine androgen signaling, mediated by steroid 5α-reductase, is essential for optimal decidualization and vascular development in the endometrium during pregnancy, indicating potential targets for improving age-related fertility issues.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, primary cilia were found to contribute to meibomian gland enlargement and lipid production, though they are not necessary for normal gland development.
March 2022 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that individuals with blood type O had a higher risk of developing post-COVID-19 syndrome compared to non-O blood types.
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study suggests that typical skin lesions in Carney complex may originate from the pro-melanogenic activity of a specific dermal fibroblast population influenced by PKA signaling.
January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that inhibiting the gp130 Y814 signaling module promotes tissue regeneration and may prevent pathological outcomes after injury in animal models.
November 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that 4-aminopyridine, a potassium channel blocker, greatly improves skin wound healing by accelerating wound closure, enhancing tissue regeneration, and promoting hair follicle neogenesis.