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This review explores the effects of caffeine on cancer, cardiovascular, immunological, inflammatory, and neurological diseases, including its use in sports, and discusses advancements in caffeine delivery through novel nanocarrier-based formulations.

This review highlights that pomegranate exhibits promising beneficial effects in preclinical and clinical studies for cardiovascular and non-cardiovascular diseases, though further research is needed on its bioavailability and metabolites for effective therapeutic use.

This review outlines the adverse effects of glucocorticoid excess on bones, adipose tissue, brain, and skin, with a focus on the Wnt/β-catenin pathway, and reports no new research findings.

This review assesses existing knowledge about the 17q21.31 inversion polymorphism, highlighting its genetic structure differences across ancestries, associations with various diseases, and implications for precision medicine and drug discovery.

This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.

This review provides an overview of natural product-derived small molecule modulators of the Wnt signaling pathway, exploring their potential as therapeutic agents for tissue regeneration and cancer treatment.

This review provides an overview of caffeine's effects on cancer, cardiovascular, immunological, inflammatory, and neurological diseases, highlighting both its potential benefits, such as neuroprotection and anti-aging, and possible adverse effects like elevated blood pressure, anemia, and migraine.

This study identified several significant genetic variants associated with alopecia universalis, including a novel association with HLA-DRB5, which may play a hidden role in the disease.

This review discusses recent advances in understanding Merkel cell carcinoma biology, including the development of genetically-engineered mouse models and potential therapeutic targets, but reports no new clinical results.

Ceramide Synthase 4 is crucial for healthy skin barrier function.

In this study, consuming a healthy, plant-based diet was associated with reduced skin inflammation and improved overall skin health, while the potential benefits of probiotics, synbiotics, and postbiotics for skin inflammation and tissue regeneration require further investigation.

This review discusses the physiological roles of anthrax toxin receptors CMG2 and TEM8, highlighting their influence on extracellular matrix homeostasis, angiogenesis, cell migration, and skin elasticity, and reports no new clinical results.

This study found that both alcoholic and aqueous extracts of Punica granatum L. showed potential for promoting hair growth and exhibited anti-lice and antidandruff activities in a mouse model.

This review discusses the use of nanomaterials in cosmetics, highlighting their benefits like enhanced stability and skin penetration, while also noting potential health risks and the role of natural ingredients in formulations.

This review summarized and classified 32 approved synthetic and natural-identical antioxidants, examining their regulatory status, safety, pharmacological properties, and effectiveness on human health, aiming to clarify their antioxidant actions and encourage further research in the field.

This study found that loss of epidermal PPARγ in mice altered the expression of many genes related to skin inflammation, keratinization, and sebaceous gland function, indicating its key role in maintaining skin homeostasis.

This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.

This review examines the anti-alopecia effects of plant-derived phytochemicals and their mechanisms for promoting hair growth, but it reports no new clinical findings.

This study suggests that the intestinal microbiota may have protective effects against celiac disease by degrading gluten and maintaining intestinal barrier integrity, but disruptions in the microbiota can exacerbate the disease.

This review discusses the structural properties, pharmacological effects, and clinical applications of neurotoxins on synapses, reporting no new experimental results.

This review explores skin microbiome composition and its ecological interactions, highlighting the role of host and environmental factors in shaping the microbial community, but provides no new research findings.

In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

This review discusses the dermatological applications and potential health benefits of Epigallocatechin-gallate (EGCG) from green tea, but provides no new clinical findings.

This review discusses the role of exosomes in medical aesthetics, focusing on their mechanisms, production, and preservation, but reports no new clinical results and highlights barriers to their widespread application.

This review highlights the inadequacy of the "specificity paradigm" in drug design for complex diseases like Alzheimer's and cancer, suggesting a shift toward developing multitarget drugs to improve treatment efficacy by interacting with multiple targets through various mechanisms.

This review discusses the role of heparan sulfate proteoglycans in regulating stem cell fate and highlights their potential as targets for addressing hair loss, without reporting new clinical results.

This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.

This review highlights capsaicin's chemical properties, natural sources, and its potential benefits such as antioxidant, anti-inflammatory, and analgesic effects, while also noting its challenges in food applications regarding dosage, taste perception, and regulatory compliance.

This review highlights that nano-antioxidants show promise as a treatment strategy for immune-mediated inflammatory diseases, like autoimmune and chronic inflammatory conditions, due to their improved stability and targeted delivery, but notes that further research is necessary to optimize their use and assess long-term safety.

This study found that chitosan nanoparticles containing Cordyceps militaris effectively reduced lung damage in mice exposed to fine particulate matter (PM2.5) by decreasing oxidative stress and preserving lung barrier integrity, suggesting potential as a therapeutic candidate for PM2.5-induced lung diseases.