October 2015 in “Elsevier eBooks” Aldesleukin can treat certain cancers and increase HIV patient CD4+ counts but often causes severe side effects.
3 citations
,
October 2025 in “Dentistry Journal” This study investigated different centrifugation systems and found that low-speed protocols and certified centrifuges produced better-quality platelet-rich fibrin and recommended using FDA-approved glass tubes for safe and effective regenerative outcomes.
7 citations
,
October 2024 in “Livers” This review highlights the connection between sex hormones and metabolic dysfunction, emphasizing how conditions like male hypogonadism and female hyperandrogenism can increase the risk and severity of hepatic steatosis, which often progresses alongside metabolic syndrome and elevates mortality risks.
January 2024 in “Diagnostics” This literature review found that Long COVID is a complex condition involving multiple body systems, influenced by factors like pre-existing conditions and vaccination status, with differing manifestations and persistence, complicating diagnosis and treatment efforts.
10 citations
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January 2019 in “Archives of Endocrinology and Metabolism” This source reports that testosterone therapy may mildly improve sexual desire in women with sexual dysfunction but lacks long-term safety data and cannot be widely recommended, as no formulations are approved for women in most countries.
1 citations
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February 2024 in “Journal of nanobiotechnology” This review explores how combining extracellular vesicles with hydrogels and utilizing 3D bioprinting technologies creates innovative composite systems for wound healing, offering advanced mechanical and biological support, while addressing challenges like degradation and regulatory issues in clinical applications.
5 citations
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May 2025 in “Pharmaceutics” In this review, researchers evaluated sericin-based drug delivery systems for antimicrobial, anticancer, and neurodegenerative treatments, highlighting its potential benefits and challenges related to molecular variability and formulation stability, suggesting future focus on optimizing extraction and integration with advanced biomedical technologies.
October 2025 in “Bioactive Materials” This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.
61 citations
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April 2023 in “Bioactive Materials” This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.
1 citations
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April 2024 in “Metabolites” In this study, researchers found that male and female APCHi mice exposed to ionizing radiation showed near-normal lipid and metabolite levels, suggesting activated protein C may offer some protective effects against radiation-induced damage affecting organ systems.
February 2024 in “Biomedicines” This study found that NKB placental mRNA expression was higher in women with PCOS, particularly in pregnancies with female offspring, suggesting its involvement in PCOS-related placental dysfunction.
11 citations
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May 2021 in “Journal of Ovarian Research” This review discusses how high estrogen levels in African women might contribute to lower COVID-19 rates and fatalities, reports no new clinical results, and suggests considering these factors for future pandemics.
8 citations
,
May 2023 in “Gels” This review discusses the advantages and progress of chitosan hydrogels in vascular regeneration for tissue engineering scaffolds, highlighting modifications to enhance their application and exploring future prospects.
5 citations
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January 2024 in “Reproductive Medicine and Biology” In this review, extensive analysis using conditional mutant mice revealed that androgen and Wnt signals play crucial roles in the development and function of male external genitalia and erectile tissue, while also exploring various regulatory factors involved in their pathogenesis.
151 citations
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May 2021 in “Frontiers in Medicine” This systematic review observed that a significant number of COVID-19 patients report long-term symptoms, including neurologic complaints and chronic fatigue, highlighting the presence of "post-COVID syndrome.
35 citations
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May 2023 in “International Journal of Preventive Medicine” This review discusses the various aspects of long COVID, highlighting its multi-organ impact, including symptoms like fatigue and dyspnea, and suggests that vaccination may play a role in prevention and management. Risk factors and potential therapeutic strategies are also examined.
44 citations
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April 2023 in “Frontiers in Molecular Biosciences” This narrative review outlines the diverse symptoms and possible mechanisms behind long COVID, such as immune dysregulation and viral persistence, while discussing ongoing and potential treatments, highlighting the current lack of proven effective therapies.
23 citations
,
January 2017 in “Journal of Functional Biomaterials” This review examines the major biomaterials used in skin wound healing and evaluates experimental therapies but reports no new research findings.
7 citations
,
March 2023 in “Pharmacy” In this study, a community pharmacy-based intervention in Serbia was associated with significant improvements in clinical symptoms for patients with post-COVID syndrome.
4 citations
,
December 2022 in “International Journal of Molecular Sciences” This review discusses the role of zinc and its transporters in skin health and disorders, providing an overview without presenting new clinical results.
2 citations
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September 2025 in “Journal of Clinical Medicine” This review highlights the promise of small extracellular vesicles (sEVs) as biomarkers for sepsis, emphasizing their potential to improve early detection and guide therapeutic decisions by reflecting the immune status and pathogen presence in patients.
25 citations
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November 2022 in “Frontiers in Bioengineering and Biotechnology” This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.
2 citations
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January 2022 in “Genetics Research” This study found that using hemocoagulase combined with platelet-rich plasma during total hip replacement surgery led to reduced perioperative blood loss and improved early joint range of motion in osteoarthritis patients.
559 citations
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October 2020 in “Frontiers in Molecular Biosciences” This review reports on the current state and potential of solid lipid nanoparticles for drug delivery, emphasizing their safety, biocompatibility, and ease of production, and highlights challenges in translating them to clinical practice, including active clinical trials.
353 citations
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February 2022 in “Nature Immunology” This review explores post-COVID-19 syndromes and the underlying mechanisms, including persistent inflammation, autoimmunity, and possible viral reservoirs, but reports no new clinical results.
29 citations
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December 2019 in “Transfusion and Apheresis Science” This review discusses platelet-derived bio-products for tissue regeneration in various medical fields and reports no new clinical results; it highlights the need for a standardized classification to compare clinical outcomes effectively.
26 citations
,
January 2025 in “iScience” This article reviews the potential applications, benefits, and limitations of platelet-rich plasma in medical practice and reports no new clinical results, emphasizing the need for standardized preparation and treatment protocols.
14 citations
,
February 2023 in “Frontiers in Bioengineering and Biotechnology” This review details various components used in hydrogel composites for treating chronic diabetic ulcers and highlights potential future materials but reports no new empirical findings.
13 citations
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September 2023 in “Medical Gas Research” This review explores the molecular mechanisms and potential roles of nitric oxide in COVID-19 therapy, but provides no new clinical results.
3 citations
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June 2023 in “MedComm” This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.