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This study identified nine compounds that activate Wnt signaling, with aminoacridine and proflavine especially promoting hair and nail regeneration in mouse models, highlighting new therapeutic candidates from existing FDA-approved and natural compounds.

This study reported that an HS-associated NCSTN mutation in iPSC-derived skin organoids led to altered hair follicle stem cell differentiation and increased expression of proteins linked to HS inflammation.

This review discusses the regulation of involucrin gene expression, focusing on transcription factors and signaling pathways, and reports no new experimental findings.

In this study, the researchers reported that activin B combined with bone marrow-derived mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats by promoting cell migration through the ERK and JNK pathways.

This review discusses how transposable element activation may hinder tissue regeneration and explores mechanisms to control this activity, reporting no new experimental results.

This study found that cytoplasmic nucleic acids significantly increase the expression of certain chemokines in human keratinocytes through NF-κB activation, though the specific receptors involved remain unidentified.

This study found that JAK1 and JAK2 inhibitors increase β-catenin activity in human hair follicle cells, suggesting an additional therapeutic mechanism for treating severe alopecia areata.

This study demonstrated that HOXC13 directly influences hair keratin gene expression by binding to specific DNA motifs, suggesting its role in early hair follicle differentiation.

Activin A and Follistatin affect how mouse hair follicles grow.

This study found that small molecule AP-1 inhibitors may selectively target SMO inhibitor-resistant basal cell carcinoma cells characterized by specific markers, potentially enhancing combinatorial cancer therapies.

This study suggests that activating AMPK to phosphorylate ZDHHC13 may enhance MC1R function and reduce melanoma risk in individuals with red hair.

This review discusses the role of activin signaling in hair follicle formation, hair growth cycling, and skin healing, but presents no new clinical findings.

This study found that the hairless gene product (Hr) suppresses VDR-mediated gene activation by directly interacting with the vitamin D receptor, potentially affecting hair follicle function.

This study identified transcription elongation as a crucial regulatory factor in adipocyte cell fate, showing that the elongation factors Spt4 and Spt6 are essential for proper adipogenic differentiation by aiding RNA polymerase II progression through key adipogenic genes.

This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.

This study found that RSPO1, a Wnt/β-catenin pathway agonist, significantly induces insulin-producing β cell replication and neogenesis in various settings, offering a promising potential therapy for diabetes.

This study found that kojic acid and niacinamide were the most effective inhibitors of UVB-induced NF-κB activation and IL-6 secretion in HaCaT keratinocytes, suggesting a role in modulating melanotrophic factor synthesis.

This study introduces stem cell activity as a key factor influencing the effects of IFN-γ and TGF-β1 on autoimmune disease dynamics, showing that varying cytokine levels can modulate stem cell activity and immune privilege, impacting tissue regeneration and disease flares.

Early sunburn treatment with certain inhibitors may reduce skin cancer risk.

This study identifies Activin A and follistatin as key regulators of hair cell differentiation in the mouse auditory sensory epithelium, influencing the timing and pattern of hair cell development.

This study found that activating CXCR2 on ras-transformed keratinocytes promotes migration and tumor development in a mouse skin model.

In this study, HDAC inhibitors promoted the differentiation of rat C6 glioma cells through the production of 5α‐reduced neurosteroids, enhancing serotonin-stimulated BDNF gene expression.

This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.

This study found that RXRα/RARγ heterodimers are necessary for retinoic acid-induced keratinocyte proliferation in the skin, while normal epidermal maintenance does not require RAR-mediated signaling.

This review discusses the roles and mechanisms of chromatin remodelers and their subunits in mammalian development, but reports no new experimental results.

In this study, researchers found that inhibiting IKKα in patient-derived CCS tumour models reduces tumour viability, supporting the potential for topical IKKα inhibitors as a treatment for CCS.

In this study, activation of c-MycER in adult mouse epidermis rapidly induced proliferation and disrupted keratinocyte differentiation, causing changes similar to precancerous lesions, which regressed once c-MycER was deactivated.

This study demonstrated that switching aE-catenin to aT-catenin in murine skin substantially rescued hyperproliferative and pre-cancerous conditions, but led to partial baldness, indicating potential functional discrepancies.

In this study, targeting ornithine decarboxylase overexpression to hair follicle keratinocytes in mice was sufficient to promote skin tumor development without additional tumor promoters.

This study identified Activin A and follistatin as key regulators of hair cell differentiation in the mammalian auditory sensory epithelium, with Activin A signaling influencing the timing and pattern of cell differentiation.