22 citations
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August 2020 in “Journal of the American Academy of Dermatology” Women with lichen planopilaris and frontal fibrosing alopecia often have other health issues like hypothyroidism and lupus.
6 citations
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May 2024 in “Clinical and Experimental Dermatology” According to this systematic review, children with alopecia areata experience significant psychosocial impacts, including anxiety, depression, and lower self-esteem, which are exacerbated by increased disease severity and affect quality of life, academic performance, and social interactions.
2 citations
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January 2018 in “Annals of Dermatology” This review discusses the potential association between androgenetic alopecia and metabolic syndrome, and notes AGA might be linked to arterial stiffness; it reports no new clinical findings and calls for further research.
1 citations
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January 2024 in “Journal of the Egyptian Womenʼs Dermatologic Society” This study found that ocular comorbidities, particularly errors of refraction, are common in patients with Alopecia Areata, but dermoscopic findings are not predictive of these ocular issues.
July 2026 in “Dermatology and Therapy” This study highlights that dissecting cellulitis of the scalp affects a diverse racial population and is associated with male sex, metabolic dysfunction, and psychiatric comorbidities, challenging its traditional characterization as primarily a disorder of Black men.
June 2026 in “British Journal of Dermatology” This study found that individuals with frontal fibrosing alopecia have increased odds of thyroid disease, lupus erythematous, vitiligo, and heart disease, supporting the consideration of FFA as a systemic disorder.
March 2026 in “Dermatology Online Journal” In this study, androgenetic alopecia was linked to a higher likelihood of hyperlipidemia in both men and women and obesity in women, highlighting it as a potential marker for cardiometabolic risk.
February 2026 in “Skin Appendage Disorders” This study found a significant association between pseudofolliculitis barbae and mood disorders such as depression and anxiety, but not with obsessive-compulsive disorder.
February 2026 in “Boletín Médico del Hospital Infantil de México” This study suggests pediatric patients with alopecia areata may benefit from screening for atopic, autoimmune, and psychiatric comorbidities to enable timely identification and treatment.
November 2025 in “Journal of Clinical Medicine” This review article explores the potential systemic nature of alopecia areata, highlighting the association with ocular abnormalities and suggesting that shared pathogenic pathways may lead to eye symptoms occurring at younger ages than usual.
August 2025 in “Dermatology and Therapy” This study found that among US adults with vitiligo, the most prevalent autoimmune comorbidities were thyroid disease and alopecia areata, with evidence suggesting greater vitiligo extent increases prevalence of several autoimmune conditions.
114 citations
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March 2021 in “Scientific Reports” This study found that, among COVID-19 patients in South Korea, hypertension, diabetes, and other comorbidities significantly increased mortality risk, with the age-adjusted Charlson comorbidity index being a strong predictor of death.
1 citations
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January 2022 in “Medical Science” This study found that patients with Alopecia Areata, particularly those with severe forms, exhibited higher triglycerides, cholesterol, and low-density lipoproteins, suggesting increased cardiovascular risk factors.
August 2020 in “Research Square (Research Square)” This study found that an age-adjusted Charlson comorbidity index of four or more strongly predicts mortality in South Korean COVID-19 patients, highlighting the impact of comorbidity burden and older age on disease severity.
49 citations
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January 2018 in “Immunology” This review discusses the relationship between psoriasis and autoimmunity, focusing on autoimmune co-morbidities, but reports no new research findings.
1 citations
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August 2025 in “Journal of Diabetes and its Complications” This review found that among young adults with type 1 diabetes, hearing loss prevalence ranged from 22.6% to 48.0% and was associated with age, diabetes duration, and systolic blood pressure, while peridontitis and alveolar bone loss also showed varying prevalence patterns.
34 citations
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March 2015 in “Clinical and Experimental Dermatology” This study observed that patients with pemphigus have a higher incidence of hypothyroidism, inflammatory bowel disease, and diabetes compared to the general population.
10 citations
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December 2018 in “Internal Medicine” This study reports two cases of myasthenia gravis patients with thymoma who exhibited various autoimmune symptoms including alopecia, suggesting a link between thymus-related immune dysregulation and comorbid conditions.
5 citations
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August 2024 in “Frontiers in Immunology” In this study, upadacitinib was reported as effective in rapidly treating psoriasiform eczema in five male patients and showed varying degrees of effectiveness on other immune-mediated comorbidities like alopecia areata, vitiligo, ulcerative colitis, and hidradenitis suppurativa.
4 citations
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March 2025 in “Pediatric Dermatology” This review examines the clinical presentation of alopecia areata in children and compares it to adult-onset cases, noting that data on pediatric cases is scarce and often varies, with reported onset typically between ages 6 and 12.
1 citations
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February 2025 in “Frontiers in Medicine” This study found that patients with juvenile-onset systemic lupus erythematosus have a high prevalence of endocrine and metabolic comorbidities, particularly dyslipidemia and obesity-related issues, suggesting the need for routine monitoring and obesity prevention.
July 2026 in “Journal of Investigative Dermatology” This retrospective cohort study found that individuals with alopecia totalis or universalis have a higher prevalence of systemic autoimmune diseases, particularly endocrine diseases and inflammatory bowel disease, compared to those with patchy alopecia areata.
September 2023 in “International journal of women’s dermatology” This study found mixed evidence linking traction hairstyles, previous pregnancies, chemical hair relaxers, and several comorbidities to an increased risk of central centrifugal cicatricial alopecia in Black women.
386 citations
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April 2006 in “PubMed” This review discusses the prevalence and treatment of benign prostatic hyperplasia and reports no new findings; it emphasizes considering side effects and comorbidities in therapy choices.
2 citations
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May 2025 in “Journal of Clinical Medicine” This study reported that in a case series of three adolescents with alopecia areata and atopic dermatitis, treatment with 15 mg/day of upadacitinib led to rapid improvement in skin symptoms and significant hair regrowth over 12 months, with no severe adverse events observed.
23 citations
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April 2017 in “Clinical, Cosmetic and Investigational Dermatology” This review discusses the importance of recognizing and treating psychiatric conditions in dermatology patients, offering practical recommendations for dermatologists to manage psychocutaneous diseases effectively, but reports no new clinical results.
3 citations
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May 2025 in “Archives of Gynecology and Obstetrics” In this study, researchers reported that women with polycystic ovary syndrome in a German-speaking population had higher probabilities of depression, anxiety, sleep disorders, and obstructive sleep apnea, all associated with BMI and insulin resistance.
4 citations
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February 2024 in “Biomedicine” The authors concluded that specific comorbidities and complications increase the risk of severe COVID-19 and impede patient recovery, making them critical factors to control in order to lessen the disease's adverse effects.
April 2023 in “JAAD international” This study observed that among a Moroccan population with frontal fibrosing alopecia, common comorbidities included lichen planus pigmentosus (36.8%), rosacea (28.9%), thyroid disorders (23.7%), and dyslipidemia (21.1%), highlighting potential relationships mediated by shared inflammatory or metabolic pathways.
April 2019 in “Journal of Investigative Dermatology” This study suggests that hormone replacement therapy and oral contraception may have a protective role in scarring alopecia, as these were reported less frequently by patients with the condition compared to those with female pattern hair loss.