29 citations
,
October 1988 in “Journal of Steroid Biochemistry” This review discusses the use of antiandrogens for various conditions like prostate cancer and highlights their potential benefits in remission rates and symptom improvement, but it reports no new clinical results.
28 citations
,
January 2022 in “PLoS ONE” This study reports that a sarcoptic mange outbreak, likely originating from mange-infected llamas from a governmental program, dramatically reduced vicuña and guanaco populations in San Guillermo National Park, Argentina.
28 citations
,
November 2014 in “Current Diabetes Reports” This review discusses the complex links between polycystic ovary syndrome, insulin resistance, and potential metabolic risks starting in adolescence, noting the need for early screening and treatment but reports no new clinical results.
28 citations
,
May 1986 in “Clinics in endocrinology and metabolism” This review discusses the potential of 4-azasteroids as 5α-reductase inhibitors for treating hirsutism, reporting their promising effects in animal studies but noting no clinical trials have been conducted yet.
27 citations
,
September 2018 in “Skin appendage disorders” This review suggests that hair transplantation may be a viable treatment option for certain primary scarring alopecias, although findings should be interpreted cautiously due to possible publication bias favoring positive results.
27 citations
,
September 2017 in “Journal of Medicinal Food” In this study, researchers found that a polyphenolic extract from Annurca apples, high in procyanidin B2, increased hair growth, density, and keratin content in healthy subjects after 2 months of use, and stimulated keratin biosynthesis in vitro.
26 citations
,
October 2016 in “Clinics in Dermatology” This article discusses various hormonal therapies for acne and provides practical treatment guidelines for managing hormonally related acne, but it reports no new research findings.
26 citations
,
December 2019 in “Neurobiology of Stress” This review discusses adverse effects of 5 alpha-reductase inhibitors, particularly persistent side effects such as post-finasteride syndrome, and highlights the need for further investigation.
26 citations
,
February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
25 citations
,
July 2024 in “Frontiers in Pharmacology” Gepant medications for migraines show varied safety profiles in this study, with specific adverse events reported across systems like gastrointestinal and skin disorders, highlighting the need for tailored treatment and monitoring.
25 citations
,
February 2012 in “The Journal of Sexual Medicine” In this study, oral finasteride treatment for four weeks reduced the weight of the corpus cavernosum in rats but did not significantly affect erectile function.
24 citations
,
October 2022 in “Revista Brasileira de Farmacognosia” This review discusses the pharmacological actions of mangiferin and the potential of delivery carriers to overcome its limitations, but reports no new clinical results.
24 citations
,
September 2018 in “Lasers in Surgery and Medicine” This study shows that multiphoton microscopy can non-invasively distinguish between scarring and non-scarring alopecia by identifying certain morphological features, but further research is needed to confirm its clinical utility.
24 citations
,
December 2013 in “Sexual medicine reviews” This review discusses persistent sexual and nonsexual adverse effects of the 5α-reductase inhibitor finasteride in younger men, including erectile dysfunction, low libido, and depression. It reports no new clinical results but emphasizes further research is needed.
24 citations
,
July 2013 in “Oncologist” This study suggests that the combination of bendamustine and rituximab is at least as effective and possibly offers a better therapeutic index than other standard regimens as first-line treatment for certain lymphoma patients.
24 citations
,
June 2010 in “Clinics in Dermatology” This review discusses various potential adverse effects of common oral vitamin and mineral supplements used in dermatology and highlights lesser-known issues like hematologic and neurologic effects from zinc.
23 citations
,
February 2021 in “Journal of Endocrinological Investigation” This review discusses the impact of COVID-19 on the endocrine system and reports no clinical results; the authors emphasize the need to investigate endocrine damage during and after COVID-19 infection.
23 citations
,
April 2018 in “Journal der Deutschen Dermatologischen Gesellschaft” This review discusses the classification and diagnosis of primary cicatricial alopecias and reports no new clinical results; it highlights the need for effective treatments owing to limited evidence of current therapies' efficacy.
23 citations
,
June 2017 in “Drug Design Development and Therapy” This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.
23 citations
,
November 2001 in “Archives of Dermatology” This review discusses recent advances in the genetic understanding of inherited hair and nail disorders and reports no new clinical results.
23 citations
,
January 2001 in “International journal of toxicology” This review discusses the cosmetic use and safety of Hypericum Perforatum Extract and Oil, finding that current data are insufficient to support their safety in formulations due to a lack of comprehensive testing.
23 citations
,
July 1993 in “Pharmacotherapy” Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.
22 citations
,
January 2002 in “Treatments in endocrinology” This review examines the role of androgens in cutaneous disorders and the potential therapeutic effects of different oral contraceptives, noting variations in individual responses and the influence of genetic and local factors but reports no new clinical results.
22 citations
,
March 2021 in “Journal of Cutaneous Medicine and Surgery” This review discusses the integration of ultrasound in dermatology for improved lesion visualization and diagnosis, highlighting recent technological advancements like handheld devices and high-frequency probes, and reports no clinical results.
22 citations
,
January 2013 in “Journal of The American Academy of Dermatology” This review discusses the role of contraceptives in dermatology, particularly for acne treatment and managing patients on teratogens, but reports no new clinical results.
22 citations
,
January 2006 in “International Journal of Andrology” This study found that coadministration of 5α-reductase inhibitors with oral testosterone in oil significantly increases serum testosterone levels in medically castrated men compared to testosterone alone, with food intake minimally affecting these levels.
22 citations
,
October 2001 in “Biochemical Pharmacology” This study found that GI198745 acts as a time-dependent inhibitor of rat 5α-reductase type 2 but a rapid-equilibrium inhibitor of type 1, potentially making it more effective than finasteride in preventing rat prostate growth.
21 citations
,
January 2019 in “Lasers in Medical Science” This review found that low-level laser therapy significantly increased hair density in adults with androgenic alopecia compared to sham treatments, with greater effects observed at lower treatment frequencies.
21 citations
,
August 2016 in “Translational Andrology and Urology” This review discusses the pathophysiology of delayed ejaculation, highlighting the role of various biogenic and psychogenic factors, but reports no new clinical findings.
20 citations
,
December 2016 in “Neurodegenerative disease management” This study found that teriflunomide, an oral medication taken once daily, significantly slowed disability progression in patients with relapsing multiple sclerosis, supported by positive results in two Phase III trials and supplemented by various analyses including long-term studies and patient-reported outcomes.