36 citations,
October 2015 in “Cell reports” Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.
130 citations,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
8 citations,
June 2022 in “Scientific Reports” LGR5 is a common marker of hair follicle stem cells in different animals and is important for hair growth and regeneration.
35 citations,
January 1993 in “International Journal of Dermatology” People with HIV and low T cell counts have more hair and scalp problems.
4 citations,
May 2021 in “The American Journal of Surgical Pathology” Cutaneous Lymphadenoma is a unique skin tumor with specific protein markers and common gene mutations that may cause continuous cell growth.
277 citations,
July 2002 in “Molecular Endocrinology” Removing part of the vitamin D receptor stops vitamin D from working properly.
87 citations,
February 2004 in “Plastic and Reconstructive Surgery” Hair follicle stem cells helped heal a severe scalp burn without needing traditional skin grafts.
81 citations,
November 2012 in “Journal of the National Cancer Institute” The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.
4 citations,
November 2006 in “Dermatologic Surgery” Transplanted transected hair follicles can survive but grow at unsatisfactory rates and are thinner, suggesting limited potential for unlimited donor hair supply.
2 citations,
February 2016 in “British Journal of Dermatology” Bimatoprost solution 0.03% is effective for treating sparse eyelashes.
February 2011 in “Journal of Investigative Dermatology” New findings suggest targeting IL-23 could treat psoriasis, skin cells can adapt to new roles, direct conversion of skin cells to blood cells may aid cell therapy, removing certain tumor cells could boost cancer immunotherapy, and melanoma may have many tumorigenic cells, not just cancer stem cells.
July 1997 in “Journal of Cutaneous Medicine and Surgery” Finasteride significantly increases scalp hair and prevents hair loss in young and middle-aged men.
133 citations,
May 2016 in “Cell Host & Microbe” Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
4 citations,
January 2011 in “Cell stem cell” Hair follicle stem cells can return to their original niche and help regenerate hair.
4 citations,
January 2010 in “Elsevier eBooks” Natural ingredients are seen as safe and effective in cosmetics, and plant tissue culture is becoming key for ingredient supply.
August 2023 in “International Journal of Molecular Sciences” Human skin xenografting could improve our understanding of skin development, renewal, and healing.
41 citations,
February 2001 in “Current pharmaceutical design” Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.
23 citations,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.
20 citations,
August 2022 in “Frontiers in Immunology” Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.
13 citations,
October 2002 in “Journal of Investigative Dermatology” The upper half of a human hair follicle can grow a new hair in a mouse, but success is rare.
12 citations,
June 2006 in “Anais Brasileiros de Dermatologia” The study found average numbers for different types of hair follicles in the scalp and observed differences between men and women, suggesting reasons for more common hair shedding in women.
3 citations,
January 2011 in “Annals of Dermatology” Blocking EGFR in skin cells doesn't majorly increase inflammation markers.
October 2023 in “Scientific Reports” Gene therapy helped rats with a specific type of rickets grow hair without severe inflammation.
November 2021 in “Authorea (Authorea)” PRP treatments and hair transplantation may be linked to the progression of pseudolymphoma to lymphoma.
66 citations,
December 2013 in “Nature Cell Biology” Inactive hair follicle stem cells help prevent skin cancer.
January 2022 in “Stem cell biology and regenerative medicine” Lymphatic vessels help hair follicles regenerate by interacting with stem cells.
1 citations,
January 2012 in “International journal of trichology” Sheep hair follicle cells can grow a lot but need the dermal papilla to do so.
45 citations,
December 2007 in “The FASEB journal” There are two types of stem cells in rodent hair follicles, each with different keratin proteins.
14 citations,
February 2022 in “The Journal of clinical investigation/The journal of clinical investigation” Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.
6 citations,
February 2023 in “Journal of nanobiotechnology” The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.