27 citations
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March 2018 in “Biomaterials” This study found that a cocktail of three proteins from embryonic skin can enable adult fibroblasts to regenerate hair follicles by altering gene expression and activating regenerative signaling pathways.
29 citations
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January 2014 in “Frontiers in physiology” This review examines the molecular mechanisms of the circadian clock and its effects on cardiovascular functions, proposing a novel non-invasive method using hair follicle cells to assess circadian regulation in humans, but reports no new clinical results.
November 2024 in “Journal of Cosmetic Dermatology” This study evaluated eyebrow mesotherapy with a growth factor-based cocktail in 32 women with thin eyebrows, finding high satisfaction rates (90.6%) with significant improvements in density and appearance, low pain levels, and unanimous willingness to recommend the treatment.
March 2024 in “GSC Advanced Research and Reviews” This study observed that exposure to different wavelengths of light affects opsin and clock gene responses in skin cells, suggesting potential therapeutic approaches using photobiomodulation for dermatological conditions like psoriasis and wound healing.
8 citations
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July 2019 in “Cell Proliferation” In this study, researchers developed a chemical cocktail and suspension culture method to transform human dermal fibroblasts into dermal papilla-like cells capable of inducing hair follicle formation in vitro and in vivo.
August 2017 in “Journal of The American Academy of Dermatology” This review discusses a dermatopathology textbook by Drs Hall, Cockerell, Chisholm, Jessup, Vandergriff, Motaparthi, and Elston, highlighting its detailed content and visual inclusivity of skin conditions in diverse populations, but reports no new research results.
August 2025 in “Chronobiology International” In this study, college students with an evening chronotype were found to be at greater risk for androgenetic alopecia, potentially due to altered circadian rhythms as indicated by shifts in heart rate patterns and clock gene expression in hair follicles.
January 1980 in “AFA Watchbird” This report suggests that spectral-analysis of feathers may identify toxic mineral exposure in birds, as illustrated by a cockatoo with feather loss showing high levels of aluminum and cadmium.
15 citations
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January 1993 in “DNA sequence” This study sequenced a related gene to KRT2.9 called KRT2.13, which encodes a type II keratin protein not expressed in the hair follicle, and found significant sequence homology suggesting possible gene conversion or conservation of functional sequences.
11 citations
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May 2010 in “Journal of the South African Veterinary Association” This case report describes how a treatment with mycophenolate mofetil and prednisone may be effective in managing autoimmune subepidermal blistering dermatosis in dogs while allowing for steroid reduction.
January 2024 in “Biochemical genetics” This study investigated the gene and protein expression differences in early and late feathering chickens, identifying several pathways, like JAK-STAT and WNT, potentially involved in non-Mendelian feather growth regulation.
This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
10 citations
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April 2017 in “Journal of Investigative Dermatology” The gut microbiome affects the development of alopecia areata.
6 citations
,
August 2016 in “Journal of Visualized Experiments” This article describes a method using the CUBIC protocol to clarify and visualize molecular and cellular interactions in mouse skin biopsies at single cell resolution, but does not provide new biological findings.
4 citations
,
March 2011 in “Korean Journal of Veterinary Research” This report documents the first diagnosed cases of canine eosinophilic granuloma in Korea, identified through histopathological examination of skin nodules in two dogs.
3 citations
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April 2022 in “International Journal of Molecular Sciences” This study showed that treating mouse fibroblasts with TTNPB can efficiently convert them into dermal-papilla-cell-like cells with strong hair-inducing capacity, suggesting potential for hair follicle regeneration therapies.
April 2019 in “Journal of Investigative Dermatology” Gut microbiota influences the development of alopecia areata.
205 citations
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April 2005 in “Journal of Investigative Dermatology” This study describes a system for generating hair follicles from dissociated cells in mice, suggesting that successful development requires a foundational epithelial platform.
5 citations
,
November 2024 in “Advanced Science” This study reported the establishment of a chemically defined culture system that supports tooth reconstitution and detailed how co-stimulation of specific signaling pathways can sustain tooth development stages and initiate enamel formation, providing insights into tooth regeneration mechanisms.
5 citations
,
November 2020 in “EBioMedicine” This study reports a novel diagnostic method for latent circadian rhythm sleep-wake disorder using circadian gene oscillations from hair follicle cells to improve sleep disorder differentiation and potential therapeutic intervention.
4 citations
,
July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study suggests that BLMP-1 is important for timely molting and oscillatory gene expression in C. elegans, indicating a potentially conserved mechanism for rhythmic skin regeneration.
3 citations
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May 2006 in “Dermatologic Surgery” This study found that multi-hair follicles in nonbald men are primarily oriented perpendicular to the radial line from the crown whorl, suggesting perpendicular transplant grafts might mimic natural appearance.
December 2025 in “npj Systems Biology and Applications” This study found that cold exposure disrupts the circadian rhythm in cultured human cells by reducing oscillation amplitude, which is restored upon rewarming, while human hair follicle cells showed minimal amplitude sensitivity to temperature changes, suggesting an evolutionary advantage related to Hopf bifurcation dynamics.
January 2024 in “Diabetes & metabolism journal” This review explored how the circadian system might influence diabetes development and management, highlighting mismatches like disrupted sleep-wake cycles and gene mutations that could worsen diabetes, and suggests targeting these for future diabetes prevention and treatment strategies.
September 2021 in “Physiology News” This abstract contains only graphical design information and does not report any research findings or conclusions.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
May 2006 in “Dermatologic Surgery” This study found that multi-hair follicles naturally orient perpendicular to the radial line from the crown whirl, suggesting that perpendicular transplantation of grafts could replicate this natural appearance.
This study found significant cephalometric changes in patients with skeletal Class III malocclusion treated with rapid maxillary expansion and reverse traction, demonstrating maxilla advancement and improved facial convexity.
18 citations
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June 2011 in “Cell stem cell” Two studies in Cell Stem Cell reported that human and mouse somatic cells can be reprogrammed into induced pluripotent stem cells using microRNAs, eliminating the need for ectopic protein expression.
17 citations
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September 2022 in “Genes & Genomics” In this study, researchers identified specific long non-coding RNAs involved in feather development that do not follow traditional genetic inheritance patterns in chickens.