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research Winding the clock back on female androgenetic alopecia
This article discusses female androgenetic alopecia but reports no new clinical findings.
research 715 Hunting the hair cycle clock (HCC): Evidence that mitochondrially localized MPZL3 is a key HCC element in murine and human hair follicles
This study suggests that Myelin Protein Zero-like 3 plays a crucial role in hair follicle cycling by regulating anagen and catagen phases, mediated through mitochondrial signaling mechanisms in both human and murine hair follicles.
research 583 Hair cycle regulation by a mitochondrially localized protein: Is MPZL3 a central component of the elusive hair cycle clock?
This study found that MPZL3 plays a crucial role in regulating the hair cycle clock in mice, with its absence leading to accelerated hair follicle cycling and suggesting potential therapeutic pathways for alopecia treatment.
research Repeatable Perming via Thiol–Michael Click Reaction: Using Amide Derived from Maleic Acid and Cystine
In this study, the novel thiol-Michael click perming molecule, MA2-CySS, achieved repeatable perming with reduced oxidative damage, preserving hair keratin's structure while maintaining efficiency comparable to traditional oxidative methods.
research Correction to “[Cocktail Cell‐Reprogrammed Hydrogel Microspheres Achieving Scarless Hair Follicle Regeneration]”
In this study, corrected data confirmed that AHFS seed microspheres exhibit good biocompatibility with fibroblasts, validating the initial results.
research Hair perming via thiol‐Michael click reaction: A strategy to avoid oxidative damage
This study found that using 1,4-butylenediamine bismaleimide for hair perming through thiol-Michael click chemistry offers comparable efficiency to conventional oxidative methods, with enhanced durability and reduced damage to hair fibres, preserving mechanical, color, and surface properties.
research Reconnection of cysteine in reduced hair with alkylene dimaleates via thiol‐Michael click chemistry
This study found that 1,4-n-butylene dimaleate can restore the mechanical properties of reduced hair by reconnecting disulfide bonds and improving the hair's structural integrity using a thiol-Michael click reaction, compared to untreated reduced hair.
research Growth Factor Cocktail Including Fibroblast Growth Factor 9 (Cellcurin) in the Treatment of Androgenetic Alopecia in Men and Women: A Randomized Controlled Trial
In this randomized controlled trial, researchers found that Cellcurin therapy significantly increased hair density, terminal hair, and vellus hair counts in men and women with androgenetic alopecia, compared to minoxidil control, over 12 weeks.
research Therapeutic effects of a new long-acting growth factor cocktail (Cellcurex™) injected using a microneedle on the scalp in patients with androgenetic alopecia: A split study
This study involved selecting patients with specific types of alopecia for treatment but does not report clinical outcomes.
research Hair restoration; clinical study to evaluate the efficacy of a combined treatment between specific meso hair cocktail class III device and microneedling device in different baldness patterns
The combined treatment of a specific hair cocktail and microneedling device effectively restores hair in different baldness patterns.
research Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Pattern Hair Loss
This study found that applying a growth factor cocktail including FGF9 with microneedling significantly increased hair density and diameter in patients with androgenetic alopecia, with similar results regardless of microneedle depths between 0.5 mm and 0.8 mm.
research Effect of iontophoresis with growth factor cocktail containing fibroblast growth factor 5-short applied to the scalp in patients with androgenetic alopecia – A split study
This study found that iontophoresis with growth factor cocktail including fibroblast growth factor 5-short significantly increased hair density in patients with androgenetic alopecia over 24 weeks.
research Therapeutic effects of growth factor cocktail (CellcurinTM) containing FGF5s (fibroblast growth factor 5 short) and NMN (nicotinamide mononucleotide) in patients with androgenetic alopecia: A split study
This study investigated the effects of GFC with FGF5s and NMN at a depth of 0.8 mm using a microneedle for treating hair loss, but the abstract provides no measurable results.
research FC 2-2 : Therapeutic Effects of Growth Factor Cocktail (CellcurinTM) containing FGF5s (fibroblast growth factor 5 short) and NMN (nicotinamide mononucleotide) applied on the scalp in the patients with androgenetic alopecia: a split study
This study found that treating androgenetic alopecia patients with microneedle-delivered GFC containing FGF5s and NMN increased hair density and diameter compared to normal saline.
research Therapeutic-effects-of-growth-factor-cocktail-including-fibroblast-growth-factor-9-in-patients-with-androgenetic-alopecia-a-split-study
A treatment called Cellcurin, combined with microneedling, significantly increased hair density and diameter in patients with hair loss.
research Original Article : Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle
This study found that a 0.5-mm microneedle depth was more effective than 0.3 mm for increasing hair density in AGA patients treated with a topical growth factor cocktail.
research P085 Therapeutic effects of growth factor cocktail including FGF9 scalp application in patients with androgenetic alopecia
This study found that growth factor cocktail treatment including FGF9, combined with microneedling, significantly improved hair density in androgenetic alopecia patients compared to treatment with regular GFC or normal saline.
research Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
This study found that many effects previously thought to be caused by circadian rhythm disruption in Bmal1 knockout mice are actually due to BMAL1's properties unrelated to its clock function.
research PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells
This study found that PTEN regulates the number and genomic stability of hair follicle stem cells in the skin, with its deficiency leading to increased stem cell accumulation and senescence through interactions with BMAL1 and BMI-1.
research Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease
In this study, researchers found that Elastic Net DNA methylation clocks are not accurate for distinguishing between individuals or identifying health markers, but measuring biological "noise" in stable cytosines may serve as a potential biomarker of aging and disease.
research Hair of the mouse: A skin bacteria “cocktail” gets follicles back on their feet
This study reports that skin bacteria can accelerate hair follicle regeneration and improve wound healing through IL-1β signaling, by activating keratinocytes in a pathway involving IL1R/Myd88.
research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles
A new method improves the isolation of hair follicle cells for better hair growth research.
research Force-triggered density gradient sedimentation and cocktail enzyme digestion treatment for isolation of single dermal papilla cells from follicular unit extraction harvesting human hair follicles
This study found that new methods for isolating human dermal papilla cells were more efficient than traditional methods, maintaining higher levels of specific markers and improving the cells' research potential.
research Localized Epidermolysis Bullosa Simplex (Weber-Cockayne type)
This report discusses a teenager with blistering of localized epidermolysis bullosa simplex—Weber Cockayne type, recommending referral to dermatology, and includes no new clinical trials or broader conclusions.
research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence
The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.
research The Efficacy and Safety of Dr. SKS Hair Booster Serum (a Cocktail of Micronutrients and Multivitamins) in Adult Males and Females With Androgenetic Alopecia: An Open-Label, Non-randomized, Prospective Study
In this study, the application of Dr. SKS Hair Booster Serum, containing micronutrients and multivitamins, significantly improved hair density and reduced hair fall in 1,000 patients with androgenetic alopecia over six months, with no major adverse events reported and 95% patient satisfaction.
research Disturbance of the Circadian System in Shift Work and Its Health Impact
This review discusses recent evidence on how night-shift work affects the circadian system, sleep, and alertness in shift workers, and reports no clinical results; potential impacts on health are considered.
research Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor
This review summarizes the recent advances in molecular mechanisms influencing tissue sensitivity to glucocorticoids, emphasizing novel mutations and new information on the glucocorticoid receptor's circadian rhythm and ligand-induced repression, but reports no new results.
research Estimation methods for human circadian phase by use of peripheral tissues
The authors concluded that utilizing clock gene expression from hair follicle cells may improve circadian-phase estimation in clinical settings, aiding the detection of circadian-related sleep problems despite social time constraints.