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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

The document concludes that more research is needed to reduce frequent hospital visits, addiction medicine education improves with specific training, early breast cancer surgery findings are emerging, nipple smears are not very accurate, surgery for older melanoma patients doesn't extend life, a genetic condition in infants can often be treated with one drug, doctors are inconsistent with blood clot medication, a certain gene may protect against cell damage, muscle gene overexpression affects many other genes, and some mitochondrial genes are less active in mice with tumors.

Hair regrowth from severe alopecia areata treatment with baricitinib can vary, with faster results in those with shorter hair loss duration.

The trial will test if proxalutamide is safe and effective in reducing death in severe COVID-19 patients.

High-dose vitamin D3 does not improve symptoms or quality of life in COVID-19 patients after one year.

Hirsutism is excessive male-pattern hair growth in women, often caused by hormonal imbalances, and requires ongoing treatment to manage.

Patients with severe alopecia areata felt better and less anxious or depressed when treated with baricitinib compared to placebo.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

TSH is usually the only test needed to check thyroid function in primary care.

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

Testosterone therapy seems safe and effective for transgender men with proper care, but more long-term research is needed.

Autoimmune liver diseases are likely linked to certain skin conditions like vitiligo and psoriasis.

Women with PCOS have higher levels of a certain growth factor, which can be reduced by taking metformin.

Bimatoprost is safe and improves eyelash growth in healthy kids but not in those with eyelash loss from chemotherapy or alopecia.

Finasteride and tamsulosin hydrochloride can be safely taken together without significant interaction.

Clascoterone is safe for the heart, even at high doses.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.

Antiandrogens are somewhat effective in reducing excessive hair growth in women.

Laser device increases hair density, safe for treating hair loss in men and women.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Some treatments, like corticosteroids and sensitizing agents, can help with alopecia areata, but more high-quality research is needed.

MorrF improves hair growth better than minoxidil alone.

The boy's itchy scalp and hair loss were likely due to head lice treatment.

High-dose biotin can cause false thyroid test results; stop taking biotin two days before testing to avoid errors.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Humans and pets share similar allergy mechanisms, and studying pet allergies can help treat both human and animal allergies.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Japanese patients with alopecia areata often have a higher BMI and consume more vitamin C, fruit, and retinol, which may affect their condition's development or severity.