research Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis
FOXN1 gene variants cause low T cells and immune issues from birth.
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research Prevalence and Associated Factors of Skin Diseases in Aged Nursing Home Residents: A Multicentre Prevalence Study
Nearly all elderly nursing home residents had a skin disease, with dry skin being the most common.
research Chitosan-Decorated Polystyrene-b-Poly(Acrylic Acid) Polymersomes as Novel Carriers for Topical Delivery of Finasteride
Chitosan-decorated polymersomes improve finasteride delivery for hair loss treatment.
research Erosive Pustular Dermatosis of the Scalp Following Topical Methylaminolaevulinate Photodynamic Therapy
A 93-year-old woman developed a rare scalp condition after therapy, which improved with steroids, not antibiotics.
research Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis
Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
research Epidermal Abnormalities and Increased Malignancy of Skin Tumors in Human Epidermal Keratin 8-Expressing Transgenic Mice
Mice with human skin protein K8 had more skin problems and cancer.
research Executive Summary: Heart Disease and Stroke Statistics—2011 Update
Cardiovascular disease deaths decreased but still caused one-third of U.S. deaths in 2007, with high rates of hypertension, smoking, obesity, and diabetes.
research Sex Differences in Arterial Hypertension
Women may need different blood pressure guidelines than men for heart disease prevention.
research Is Seborrhea a Sign of Autonomic Impairment in Parkinson's Disease?
Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.
research Genome-Wide Meta-Analysis Implicates Mediators of Hair Follicle Development and Morphogenesis in Risk for Severe Acne
Genetic variations affecting skin structure play a key role in severe acne.
research Effect of Finasteride 5 mg (Proscar) on Acne and Alopecia in Female Patients with Normal Serum Levels of Free Testosterone
Finasteride improves acne and hair loss in women with normal testosterone.
research Therapy and Antifungal Susceptibility Profile of Microsporum Canis
Terbinafine and itraconazole are more effective against Microsporum canis than fluconazole and griseofulvin.
research Modern Drug Delivery Strategies Applied to Natural Active Compounds
New drug delivery methods can make natural compounds more effective and stable.
research GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells
GLI2 increases follistatin production in human skin cells.
research Italian Guidelines in Diagnosis and Treatment of Alopecia Areata
The Italian guidelines offer advice for diagnosing and treating alopecia areata based on expert opinion and limited clinical trial evidence.
research Vitamin D Receptor Polymorphisms and Polycystic Ovary Syndrome: A Systematic Review
The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.
research Two Hypomorphic Alleles of Mouse Ass1 as a New Animal Model of Citrullinemia Type I and Other Hyperammonemic Syndromes
Researchers created a new mouse model for studying Citrullinemia Type I and similar conditions, showing symptoms and treatment responses like those in humans.
research Skin Permeation of Different Steroid Hormones from Polymeric Coated Liposomal Formulations
Polymers increased skin permeation and stability of steroid hormones in liposomal formulations.
research FOXN1 Deficiency: From the Discovery to Novel Therapeutic Approaches
New treatments for immune disorders caused by FOXN1 deficiency are promising.
research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation
Thymic transplantation normalized some T-cells but not others, maintaining immune function.
research Rare and Common Genetic Determinants of Metabolic Individuality and Their Effects on Human Health
Genetic variations greatly affect individual metabolism and can impact health and disease risk.
research The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride
Pregnancy reduces anxiety in rats, but finasteride reverses this effect.
research Effects of Non-Ablative Fractional Erbium Glass Laser Treatment on Gene Regulation in Human Three-Dimensional Skin Models
Erbium glass laser treatment may help with skin remodeling, reduce inflammation, and improve skin cell maturation.
research A Multicenter Placebo-Controlled Clinical Trial on the Efficacy of Oral Ciclosporin A in the Treatment of Canine Idiopathic Sebaceous Adenitis Compared with Conventional Topical Treatment
Oral ciclosporin A and topical treatments both reduce hair loss and scaling in dogs with sebaceous adenitis, but using both together is most effective.
research Dysplastic Nevi, Cutaneous Melanoma, and Other Skin Neoplasms in Patients with Myotonic Dystrophy Type 1: A Cross-Sectional Study
People with myotonic dystrophy type 1 have a higher chance of getting skin tumors, including melanoma.
research Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene
A mouse gene mutation increases the risk of skin cancer.
research Human Clinical Phenotype Associated With FOXN1 Mutations
FOXN1 mutations cause severe immunodeficiency, hair loss, nail issues, and thymus defects.
research Effects of Finasteride, a 5 Alpha-Reductase Inhibitor, on Circulating Androgens and Gonadotropin Secretion in Hirsute Women
Finasteride reduces dihydrotestosterone, increases testosterone, and may treat hirsutism in women.
research Testosterone Target Therapy: Focus on Immune Response, Controversies, and Clinical Implications in Patients with COVID-19 Infection
Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.
research Green Tea in Dermatology: Myths and Facts
Green tea may help with skin health and protect against UV damage, but more research is needed to confirm its safety and effectiveness.