28 citations
,
February 2014 in “Journal of Cutaneous Pathology” In this study, researchers observed that keratoacanthoma exhibits dynamic follicular differentiation throughout its stages, with changes in specific keratin expressions, and regressed lesions showing epidermal rather than follicular characteristics.
28 citations
,
September 2013 in “European Journal of Histochemistry” This study demonstrates a varied distribution of keratins in the epidermis of the Malayan pangolin, suggesting evolutionary adaptations related to their distinctive scales.
2 citations
,
May 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” This study observed that cytokeratins are expressed at specific stages during human fetal hair follicle development, with early markers indicating cellular maturation and later markers appearing in more developed follicles.
2 citations
,
September 2010 in “Acta Ophthalmologica” The study concluded that all parts of the normal human Meibomian gland ductal system show signs of early keratinisation, supporting the idea that these glands are akin to "hair follicles without a hair shaft.
April 2018 in “Journal of Investigative Dermatology” This article proposes a new classification system for cutaneous adnexal cysts based on their origin in the folliculo-sebaceous unit and sweat glands, aiming to clarify their categorization and origins.
September 2008 in “Acta Ophthalmologica” This study found that murine vibrissa hair follicle stem cells can differentiate into corneal epithelial-like cells in vitro when cultured with limbus-specific microenvironmental factors.
107 citations
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May 1999 in “Archives of Dermatological Research” In this study, the immunohistochemical and lectin binding profiles of basal cell carcinoma closely resembled those of the outer root sheath of vellus hair follicles, suggesting a potential histochemical relationship.
6 citations
,
December 1990 in “PubMed” This study examined the expression patterns of various cytokeratins in the outer root sheath of human anagen hair follicles, noting distinct differentiation patterns and localization of keratin markers.
5 citations
,
September 2009 in “Acta Ophthalmologica” This study found that the Meibomian gland shares structural and cytokeratin composition similarities with hair follicles, and plays a role in hyper-keratinisation observed in obstructive Meibomian gland dysfunction.
January 2010 in “Chinese Journal of Aesthetic Medicine” The study observed increased melanin and signs of skin aging in melasma-afflicted skin, with strong CK10 expression in the upper basal epidermis, potentially linked to excessive epidermal cell differentiation and aging.
11 citations
,
March 2024 in “Current Issues in Molecular Biology” This review discusses the pharmacological actions and potential therapeutic benefits of ginsenoside compound K for metabolic disorders, reports no new clinical results, and suggests further research on its bioavailability and toxicity.
1 citations
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February 2024 in “Preprints.org” This review discusses the pharmacology and potential therapeutic effects of rare ginsenoside compound K on metabolic disorders but presents no new clinical results, highlighting the need for further studies on its bioavailability and toxicity.
37 citations
,
August 2000 in “Journal of Cutaneous Pathology” This study found that keratin immunohistochemistry suggests neoplastic cells in eccrine and apocrine poromas are closely related to dermal sweat duct cells, but cannot differentiate these poromas based solely on keratin patterns.
2 citations
,
January 2016 in “Skin pharmacology and physiology” This study found that seed oil of Caragana korshinskii demonstrated high antifungal efficacy against Trichophyton mentagrophytes in an in vivo guinea pig model of dermatophytosis.
January 2008 in “Zhongguo zuzhi gongcheng yanjiu yu linchuang kangfu” This study found that selecting human vaginal mucosa stem cells by adhesion to type Ⅳ collagen for 20 minutes and culturing them with feeder layer and epidermal total culture media was most effective in maintaining their characteristics.
3 citations
,
January 2012 in “Wageningen Academic Publishers eBooks” This article discusses the complex biological functions and social significance of hair follicles and reports no new research findings, emphasizing their role in health, disease, and a substantial beauty industry.
April 2025 in “International Journal of Pharmaceutical Sciences Review and Research” This study found that SesZen-Bio TM, a proprietary extract from Sesbania grandiflora leaves, increased proliferation of hair cells and hair shaft length in vitro and ex vivo, potentially due to activation of the Wnt/β-catenin signaling and stem cell differentiation pathways.
This study found that hyaluronic acid increased the size of hair follicle germ-like aggregates and the number of proliferative cells but did not maintain specific markers during the process.
208 citations
,
January 2013 in “Lab on a Chip” The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.
155 citations
,
August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution” This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.
77 citations
,
April 2016 in “Science Advances” Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.
64 citations
,
December 2012 in “Stem Cell Reviews and Reports” This study reports the successful generation of inducible pluripotent stem cells from mesenchymal stem cells derived from human hair follicles, marking a novel method of reprogramming these cells.
62 citations
,
April 2009 in “British Journal of Dermatology” This review discusses the potential markers for identifying and studying stem cells in the epidermis and hair follicles, highlighting their role in understanding skin disease pathogenesis and expanding therapeutic options, but reports no new findings.
45 citations
,
October 2014 in “Stem cell research & therapy” This study found that using 3D Gel-C6S-HA scaffolds seeded with VEGF165-modified rat hair follicle stem cells enhanced angiogenesis and vascularization in tissue-engineered skin, improving wound healing.
28 citations
,
February 2014 in “PLoS ONE” This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.
23 citations
,
January 2018 in “International Journal of Molecular Medicine” This study reported that baicalin activates the Wnt/β-catenin signaling pathway in mouse hair follicles, suggesting its potential as a topical treatment for hair loss.
21 citations
,
October 2009 in “Biochemical Engineering Journal” This review discusses various approaches to treating alopecia, including drug therapy and hair transplantation, but reports no new research findings; the authors highlight the need for novel techniques like cell culturing.
20 citations
,
January 2019 in “Journal of dermatological science” This study suggests that androgens enhance growth factor production in dermal fibroblasts, which in turn may alter keratinocyte differentiation and contribute to acne lesion formation.
18 citations
,
November 2014 in “Journal of Agricultural and Food Chemistry” This study found that ethanol-extracted propolis stimulated hair growth in mice by promoting the proliferation of hair keratinocytes.
13 citations
,
June 2018 in “Dermatopathology” This classification proposal introduces a novel system for categorizing cutaneous adnexal cysts based on their origin in the folliculosebaceous unit and sweat glands, aiming to simplify and enhance understanding of these skin lesions.