43 citations
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August 2016 in “Scientific Reports” This animal study found that Cinnamomi cortex water extract reduced prostate weight and improved histological changes in a benign prostatic hyperplasia model, suggesting potential as a treatment.
24 citations
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March 2024 in “Antioxidants” In this review, researchers reported that cinnamon and ginger supplementation may benefit PCOS patients by improving hormonal status, lipid profiles, obesity, and insulin resistance through oxidative stress and inflammation reduction.
8 citations
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September 2022 in “Biointerface Research in Applied Chemistry” This review examines the pharmacological potential of quinoline alkaloids from Cinchona bark for developing new drugs and cosmetics but reports no new findings.
8 citations
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January 2020 in “Evidence-based Complementary and Alternative Medicine” This study found that Cinobufacin combined with chemotherapy improved clinical outcomes in breast cancer patients and reduced certain side effects compared to chemotherapy alone.
5 citations
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October 2021 in “Journal of Ovarian Research” This review indicates promising potential for cinnamon supplementation to improve metabolic outcomes in PCOS, but more clinical trials with higher doses and longer durations are needed to confirm these effects.
3 citations
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July 2025 in “British Journal of Dermatology” Cinainu is effective and safe for treating children's alopecia areata.
2 citations
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August 2019 in “Asian journal of pharmaceutical and clinical research” This study found that in female breast cancer patients, supplementation with 400 mg IND02 (Cinnamon bark extract) thrice daily during chemotherapy significantly reduced severe weight loss and hair loss compared to placebo, with the treatment being well-tolerated and safe.
1 citations
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January 2024 in “Pediatric Endocrinology Diabetes and Metabolism” In this retrospective study of eight Saudi children with hereditary vitamin D resistant rickets, researchers observed that adjunctive cinacalcet appeared safe and showed initial promise in improving serum PTH levels, though further investigation is needed to confirm its efficacy.
1 citations
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October 2022 in “Journal of food and nutrition research” This review investigates the potential benefits of cinnamon supplementation alongside lifestyle changes for managing obesity and polycystic ovary syndrome, but it reports no new clinical results.
1 citations
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January 2022 in “Journal of Drug Delivery Science and Technology” This study successfully developed and optimized ethanol-free microemulsion systems for the transdermal delivery of finasteride, showing that the predicted optimal formulations had physicochemical characteristics close to estimated values, without significant damage to treated hair fibers.
1 citations
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January 2022 in “Indonesian Journal of Pharmaceutical Science and Technology” This study evaluated a 20% cinchona extract cream and found it increased hair growth length and mass in guinea pigs, demonstrated good physical stability, and did not irritate rabbit skin.
1 citations
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April 2021 in “Journal of Investigative Dermatology” This study found that Manganese PCA, Cinchona succirubra, and Leontopodium alpinum extracts may promote hair growth by enhancing VEGF secretion and activating the Wnt/b-catenin pathway in Human Hair Follicle Dermal Papilla Cells.
June 2026 in “International Journal of Drug Delivery Technology” In this study using fertilized chicken eggs, researchers reported that ethanol and aqueous extracts of clove, cinnamon, and coriander significantly reduced blood vessel formation, indicating these herbs' potential as safe anti-angiogenic treatments without severe side effects compared to synthetic drugs.
March 2026 in “Physical Education Health and Social Sciences” In this randomized controlled trial, combining cinnamon and inositol led to significant improvements in metabolic and hormonal parameters, such as reduced LH, testosterone, fasting glucose, and ovarian ultrasound scores, in overweight women with PCOS, indicating superior benefits over either supplement alone.
February 2026 in “World Journal of Interdisciplinary Innovation Sciences” This systematic review found that cinnamon supplementation may modestly improve insulin sensitivity and potentially reduce hyperandrogenism in women with PCOS, but stresses the need for large-scale clinical trials.
June 2025 in “Healthy-Mu Journal” The optimized Cinchonine gel effectively fights acne bacteria and is safe for twice-daily use.
October 2024 in “JURNAL ILMU KEFARMASIAN INDONESIA” This study found that the F6 formulation of a hair tonic containing EDS and ATG extracts produced the most significant hair growth in rabbits, without causing skin irritation and remaining stable throughout the observation period.
October 2024 in “Bangladesh Journal of Botany” This study found that cinnamic acid stress inhibited root growth more in cucumber seedlings than in figleaf gourd, potentially due to differences in hormone content and production rates.
February 2024 in “Scientific Reports” In this study, cinnamic acid was found to enhance hair growth in human dermal papilla cells and hair follicle organoids by activating oxytocin signaling, suggesting its potential for developing hair growth-promoting products.
January 2024 in “Bratislavské lekárske listy/Bratislava medical journal” This study examined the vasorelaxant effects of two similar alkaloids, chloroquine and cinchonine, in a model of smooth muscle contractions induced by phenylephrine. Results are not reported in the abstract.
October 2023 in “Current Issues in Molecular Biology” In this study, researchers observed that the YH complex, made from Astragalus membranaceus and Cinnamomum cassia, promoted hair regrowth and increased hair shaft thickness in mice, potentially through increased growth factors and Wnt/β-catenin signaling, suggesting its use for treating various forms of hair loss.
October 2023 in “Jurnal Ilmu Kefarmasian Indonesia” In this experimental study using rabbits, the researchers evaluated hair tonic formulations containing cinnamon essential oil and virgin coconut oil, finding that formula 3 had hair growth activity exceeding the positive control, though overall growth activity differences were not statistically significant.
June 2023 in “Sains Malaysiana” This study evaluated the effectiveness and safety of a cinchonine nanostructured lipid carrier serum for hair growth in mouse models, finding that it significantly increased hair length and enhanced follicle penetration compared to controls, with no notable irritation observed.
May 2023 in “Jurnal farmasi sains dan praktis” In this research on cinnamon and virgin coconut oil hair tonics, F2 and F3 demonstrated stable physical properties and mild irritation potential, while formula 1 remained non-irritating but less stable regarding pH and viscosity.
In a study on hair loss treatment, researchers found that a serum containing Cinchona succirubra extract and caffeine improved hair density and reduced hair loss in individuals with acute telogen effluvium after 16 weeks of use, with significant improvements observable after just 4 weeks.
April 2023 in “Journal of Investigative Dermatology” In this clinical study, a serum containing Cinchona succirubra extract and Caffeine significantly improved hair growth and reduced hair loss in subjects with acute telogen effluvium.
October 2022 in “CRC Press eBooks” This review explores the botany, traditional uses, phytochemicals, and pharmacological activities of Cinchona pubescens but presents no new clinical findings.
August 2021 in “Research Square (Research Square)” This study found that BEO inhibited cell proliferation and inflammatory mediator release in a human keratinocyte acne model and reduced acne lesion severity in a rabbit model, suggesting its potential as a natural alternative to conventional acne treatments.
This study found that applying topical cinnamon essential oil on male wistar rats increased hair length and hair follicle diameter similarly to 2% minoxidil over 30 days.
January 2021 in “Social Science Research Network” In this study, researchers developed and optimized ethanol-free microemulsion systems for transdermal finasteride delivery, finding that the predicted formulations closely matched their physical and chemical characteristics, potentially reducing adverse effects compared to oral administration.