research Oncogenic Senescence: A Multi-Functional Perspective
Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.
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research Wound Healing: A Cellular Perspective
The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
research Apoptosis in Human Skin Development: Morphogenesis, Periderm, and Stem Cells
Apoptosis is essential for human skin development and forming a functional epidermis.
research An Integrative View of Mammalian Seasonal Neuroendocrinology
The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.
research Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing
Fibroblast state switching is crucial for skin healing and development.
research Stat3 Partly Inhibits Cell Proliferation Via Direct Negative Regulation of FST Gene Expression
The protein STAT3 slows down cell growth by blocking the FST gene, which affects hair development in sheep.
research An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice
High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.
research The Therapeutic Role of ADSC-EVs in Skin Regeneration
ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.
research Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny
The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.
research Wnt Signaling and Aging-Related Heart Disorders
Wnt signaling may be linked to heart diseases in aging and could be a target for future treatments.
research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations
Disruptions in hair follicle fibroblast dynamics can cause hair growth problems.
research Emerging Roles of Transit-Amplifying Cells in Tissue Regeneration and Cancer
Transit-amplifying cells are crucial for tissue repair and can contribute to cancer when they malfunction.
research Epigenetic Regulations on Skin Wound Healing: Implications from Current Research
Epigenetic changes are crucial for stem cell behavior in skin wound healing and their disruption may lead to cancer.
research TGF-β Family Signaling in Stem Cells
TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.
research Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle
The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.
research Repairing the Lungs One Breath at a Time: How Dedicated or Facultative Are You?
Lung repair involves both dedicated and flexible stem cells, important for developing new treatments.
research Is There Any Relationship Between Decreased AgNOR Protein Synthesis and Human Hair Loss?
Less AgNOR protein production is linked to hair loss.
research Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives
Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
research DNA Methylation as an Epigenetic Memory Keeper During Skin Development and Regeneration
DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.
research Alk1 Acts in Non-Endothelial VE-Cadherin+ Perineurial Cells to Maintain Nerve Branching During Hair Homeostasis
Alk1 in specific cells is crucial for proper nerve branching and hair function.
research Modulating the Stem Cell Niche for Tissue Regeneration
Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
research Molecular Principles of Hair Follicle Induction and Morphogenesis
Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
research Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells
Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.
research The PDGF/PDGFR Pathway as a Drug Target
The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.
research The Hair Follicle as an Estrogen Target and Source
Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.
research Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging
Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
research Effect of Estrogens on Skin Aging and the Potential Role of SERMs
Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.
research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation
TCDD speeds up skin barrier formation by increasing certain gene expressions.
research Myocardial NF-κB Activation Is Essential for Zebrafish Heart Regeneration
NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.
research TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition
The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.