research Human Skin Stem Cells and the Aging Process
Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.
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research Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth
Growing human skin cells in a 3D environment can stimulate new hair growth.
research Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss
Hair can regrow after certain stem cells are lost because other stem cells can take over their role.
research Stem Cell-Derived Motor Neurons from Spinal and Bulbar Muscular Atrophy Patients
The study suggests that motor neurons created from stem cells of patients with spinal and bulbar muscular atrophy show signs of the disease, including changes in protein levels and cell functions.
research Chrousos Syndrome: From Molecular Pathogenesis to Therapeutic Management
The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.
research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease
Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.
research Wnt1a Maintains Characteristics of Dermal Papilla Cells That Induce Mouse Hair Regeneration in a 3D Preculture System
Wnt1a helps keep cells that can grow hair effective for potential hair loss treatments.
research Atrichia With Papular Lesions Resulting From a Novel Insertion Mutation in the Human Hairless Gene
Researchers found a new mutation causing total hair loss from birth.
research Methods of Hair Loss Evaluation: A Comparison of TrichoScan with the Modified Wash Test
The modified wash test is better than TrichoScan® for diagnosing hair loss.
research Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility
Environmental factors and exposure to toxins may contribute to male infertility by affecting sperm and hormone function.
research Stem Cells and Their Niches
The document concludes that stem cells and their environments are crucial for skin and hair health and have potential for medical treatments.
research Ligand-Independent Actions of Vitamin D Receptor
The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.
research Society News
Smoking doubles the risk of blindness, and physical exercise helps dyslexic children read better.
research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs
Laminin 332 is essential for normal skin cell behavior and structure.
research Roles of Melatonin in Goat Hair Follicle Stem Cell Proliferation and Pluripotency Through Regulating the Wnt Signaling Pathway
Melatonin helps goat hair stem cells grow and maintain their ability to become different cell types.
research Targeting the Hippo/YAP/TAZ Signalling Pathway: Novel Opportunities for Therapeutic Interventions into Skin Cancers
Blocking YAP/TAZ could be a new way to treat skin cancer.
research Scratching the Surface of Skin Development
The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
research Lamins in Development, Tissue Maintenance, and Stress
Lamins are vital for cell survival, organ development, and preventing premature aging.
research Apoptosis and Cutaneous Biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research Signaling Couples Hair Follicle Stem Cell Quiescence With Reduced Histone H3 K4/K9/K27me3 for Proper Tissue Homeostasis
Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.
research Effect of Ultraviolet Radiation, Smoking, and Nutrition on Hair
Ultraviolet rays damage hair, smoking may cause hair loss, and good nutrition is important for hair health, but genetics mainly decide hair thickness.
research Genomewide Differential Expression Profiling of Long Non-Coding RNAs in Androgenetic Alopecia in a Chinese Male Population
Found different long non-coding RNAs in balding Chinese men, which may help create new treatments.
research Cornification
Cornification is the process where living skin cells die to create a protective barrier, and problems with it can cause skin diseases.
research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin
Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer
Different types of skin cells play specific roles in development, healing, and cancer.
research Estrogens and Aging Skin
Estrogen therapy can reduce skin aging but has cancer risks.
research Stem Cell Heterogeneity and Plasticity in Epithelia
Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
research The Circadian Clock in Skin
The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
research MicroRNA-302 Increases Reprogramming Efficiency via Repression of NR2F2
MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.
research Estrogen Functions in Skin and Skin Appendages
Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.