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The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

The document concludes that managing PCOS involves treating symptoms, regulating periods, and reducing health risks, with specific medications for fertility and metabolic issues.

Biotin supplementation during isotretinoin treatment for acne may help maintain skin hydration and improve hair growth.

After chemotherapy for a gestational trophoblastic tumor, normal pregnancy rates are possible, but there's a slightly higher risk of the tumor reoccurring in future pregnancies.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

PCOS symptoms change with age; younger women have higher androgen levels and less metabolic issues, while older women face more metabolic challenges despite milder PCOS symptoms.

Testosterone supplements can increase muscle mass and strength in older men with low levels, but long-term effects and risks need more research.

Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

Higher doses of oestradiol implants improve bone density in postmenopausal women.

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

Hormones like testosterone and estrogen significantly affect hair growth and structure.

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

Pregnancy can cause various skin changes, including pigmentation, acne, and stretch marks, and may affect preexisting skin conditions.

COVID-19 may harm male reproductive health and lower testosterone levels, potentially affecting fertility and causing erectile dysfunction. More research is needed.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

Reproductive hormones play a crucial role in breast cancer development and treatment challenges.

Finasteride caused enlarged breast tissue in a 62-year-old man.

Prenatally androgenized ewes can model increased hair diameter in women with PCOS.

Primary care for PCOS focuses on lifestyle changes, medication based on symptoms, and mental health, with diabetes screening and specialist referral for severe cases.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Hormone treatment before hypospadias surgery can increase penis size and reduce surgery complications.

Some common medications can harm male fertility, but many effects can be reversed.