15 citations
,
March 2020 in “Anais Brasileiros De Dermatologia” This review discusses post-finasteride syndrome, characterized by persistent symptoms despite discontinuation, and concludes that its existence cannot be confirmed; individualized assessment is advisable for those with a history of depression, sexual dysfunction, or infertility.
15 citations
,
October 2014 in “Hormone Molecular Biology and Clinical Investigation” This report advances the hypothesis that finasteride and dutasteride inhibit 5α-reductase activities, potentially altering steroid metabolism and increasing the risk of insulin resistance, diabetes, and vascular disease.
15 citations
,
January 2002 in “Gynecological endocrinology” This review discusses the extragenital effects of ovarian steroids, particularly focusing on aesthetic endocrinology, which suggests estrogens may slow skin aging post-menopause, though hair loss treatment efficacy is mainly confirmed for minoxidil.
15 citations
,
September 1984 in “Veterinary Clinics of North America: Small Animal Practice” The document explains various skin conditions in cats and how to diagnose and treat them.
14 citations
,
July 2016 in “Fertility and Sterility” This study found that increasing the follicle number criteria for diagnosing PCOS to 25 per ovary excluded some women who continue to show evidence of metabolic risk.
14 citations
,
January 2008 in “Gynecological Endocrinology” This study reports that in women with non-tumor hyperandrogenism, a decrease in serum testosterone from insulin-sensitizing therapy like metformin may indicate a low likelihood of having an androgen-secreting tumor.
14 citations
,
September 2007 in “Steroids” This study suggests that androstendione and DHEA are useful indicators for diagnosing hyperandrogenemia in hirsute women, while DHEAS was not found to be helpful.
14 citations
,
July 1987 in “Dermatologic Clinics” This article reviews current evaluation and treatment options for androgenic alopecia in women and reports no new clinical results.
13 citations
,
January 2020 in “Neuroscience” This study found that finasteride impaired object recognition memory and altered hippocampal dendritic structures in male 3xTg-AD mice, suggesting potential sex differences in Alzheimer's disease pathology.
13 citations
,
July 2019 in “Pediatric dermatology” This review addresses dermatologic health disparities in sexual and gender minority adolescents, highlighting the need for improved pediatric dermatologic care; it does not report new clinical results.
13 citations
,
November 2012 in “PubMed” This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.
13 citations
,
September 2011 in “American Journal of Clinical Dermatology” This review describes the dermatological uses of the contraceptive ethinylestradiol/chlormadinone acetate for conditions linked to high androgen levels and reports no new clinical results.
11 citations
,
September 2021 in “Journal of molecular endocrinology” This review discusses differences in ERβ signaling between rodents and humans and reports no new clinical results; the authors highlight the need for further research in humans before using ERβ agonists clinically.
11 citations
,
April 2017 in “The European Journal of Contraception & Reproductive Health Care” This review highlights that Cyproterone acetate combined with ethinylestradiol is highly effective for treating severe acne and hirsutism in women with hyperandrogenism, and it also provides benefits for cycle control and mood improvement, according to the analysis of 78 studies.
10 citations
,
February 2020 in “Endocrine” This study found that finasteride treatment in males with androgenetic alopecia was linked to significant changes in sperm parameters and increased testosterone levels, but no sexual dysfunction was observed, and sperm parameters returned to baseline after treatment stopped.
10 citations
,
January 2017 in “Expert Opinion on Pharmacotherapy” This review discusses the clinical features and treatment options for adult acne, highlighting the need for tailored management in specific populations, but reports no new findings.
10 citations
,
January 2014 in “Endocrinology & metabolic syndrome” This review summarizes the current knowledge on polycystic ovary syndrome, including its features, diagnosis, and treatment, and highlights the need for further research to fill existing knowledge gaps.
10 citations
,
April 2006 in “Seminars in Reproductive Medicine” This article reviews the limited evidence on testosterone therapy for premenopausal women and notes a lack of long-term safety and effectiveness data for this population.
10 citations
,
May 1995 in “Journal of General Internal Medicine” Most women with excessive hair growth have PCOS; treatment varies and focuses on preventing new hair, with electrolysis as the only permanent removal method.
10 citations
,
October 2020 in “Microscopy and Microanalysis” This study found that resveratrol significantly alleviated testicular damage in male rats caused by finasteride, which otherwise led to decreased testosterone levels and various histopathological alterations in the testes.
9 citations
,
December 2024 in “Clinical and Experimental Obstetrics & Gynecology” This review examines the impact of polycystic ovary syndrome on reproductive health, its pathophysiology, clinical manifestations, and emerging therapies, and reports no new findings; the authors emphasize the need for individualized treatment strategies.
9 citations
,
March 2021 in “Hormones” This review discusses how COVID-19 may affect gonadal function and potential gender differences, but reports no clinical results; it highlights possible mechanisms and new treatment approaches from recent literature.
9 citations
,
September 2020 in “Journal of Drugs in Dermatology” This study found that men have higher COVID-19 positivity, hospitalization, and death rates than women, even when accounting for age differences.
9 citations
,
November 2018 in “International Journal of Medical Reviews” This review discusses the prevalence and etiologies of sexual dysfunction in young men, highlighting the increased recognition of organic causes alongside psychosomatic factors, and reports no new clinical results.
9 citations
,
November 2015 in “Gynecological Endocrinology” This study found that among different subtypes of PCOS based on Rotterdam criteria, group A showed higher androgen levels and hirsutism, while all subtypes had increased LH and LH/FSH compared to controls.
9 citations
,
July 2009 in “Journal Of Endocrinology, Metabolism And Diabetes Of South Africa” The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.
9 citations
,
September 2000 in “Obstetrics and gynecology clinics of North America” This article reviews the psychological impact of hirsutism, particularly its prevalence among women, and provides no new clinical findings.
8 citations
,
March 2010 in “Gynecological Endocrinology” This study assessed various androgens' diagnostic effectiveness for hyperandrogenaemia in PCOS using ROC curve analysis, but it reports no specific new results.
8 citations
,
February 2010 in “Journal für Kardiologie (Krause & Pachernegg GmbH)” This study developed a detailed classification system for functional androgenization in females that may enhance diagnosis and personalized treatment by identifying individual dysfunctions.
8 citations
,
January 1987 in “Gynecological Endocrinology” This study found that treatment with the pure antiandrogen Flutamide did not affect the estrous cycle or plasma levels of most hormones in female rats, supporting its potential use for treating hirsutism, acne, and alopecia in women.