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The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

The document suggests medicine should integrate biological and cultural factors and focus on holistic, equitable care.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Female hair loss linked to metabolic syndrome, not in males.

Herbal nano-formulations show potential for effective skin delivery but need more research.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

DHT's role in hair loss is important, but measuring its level for diagnosis is questionable.

Women with PCOS have a higher risk of diabetes, heart problems, certain cancers, and mental health issues, but early treatment can help manage these risks.

The new drug delivery system releases the drug better in sebum and targets follicles more effectively than the conventional cream.

Many young Italian women have hyperandrogenic disorders like PCOS, which are linked to age, body weight, and insulin resistance.

Ion-paired risedronate significantly increases skin penetration without irritation compared to risedronate alone.

High afamin levels are linked to metabolic syndrome and may predict its development in women with insulin resistance.

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

St. John's wort increases finasteride metabolism, reducing its effectiveness; use caution when combining them.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

Brazilian women with PCOS and both menstrual irregularity and high male hormone levels have a higher chance of having metabolic syndrome.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.

The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Young women with high male hormone levels or PCOS often feel more psychological distress and have a lower quality of life.

A team approach is crucial for managing PCOS, with dermatologists playing a key role.

Gonadal hormones significantly affect the severity of alopecia areata in mice.

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

Testing for CAG repeat polymorphism in the androgen receptor gene is not currently recommended for managing hypogonadism.

Many women with PCOS have undiagnosed health issues and show different symptoms based on the clinic they visit.

Three specific proteins can turn adult skin cells into hair-growing cells, suggesting a new hair loss treatment.

PCOS is a complex disorder managed by treating symptoms and requires a team of specialists.