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Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

The pumpkin seed oil niosomes are promising for skin and hair treatments because they are stable and effectively deliver the oil.

Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.

People with early hair loss may have a higher chance of enlarged prostate and metabolic syndrome, so they should be checked for urinary and metabolic issues.

The document concludes that scalp health is influenced by complex factors affecting sebaceous glands, including hormones, aging, and various substances.

Low-level Laser Therapy may help reduce inflammation, pain, and aid healing, but more research is needed to confirm its effectiveness and establish standard treatment guidelines.

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Male and female skin differ in many ways, which could lead to gender-specific skin treatments.

Lifestyle changes can improve body composition, excess male hormone levels, and insulin resistance in women with PCOS.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Finasteride effectively treats baldness but may cause sexual side effects.

Improving skin barrier and using antifungal treatments can help manage dandruff.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Triparanol therapy can cause hair loss and skin dryness without inflammation or damage to hair follicles or skin structures.

Niosomes are promising for skin drug delivery, offering benefits like improved drug penetration and stability.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Hirsutism is a strong sign of high male hormones and metabolic problems in women with PCOS, but acne and hair loss are not.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Mutations in the LSS gene cause a rare type of hereditary hair loss.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Melatonin improved mental health and metabolism in women with PCOS.

Isotretinoin is safe and effective for acne, with common side effects like dry lips; serious side effects are rare.