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High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Trilostane effectively and safely treats dogs with pituitary-dependent hyperadrenocorticism, improving symptoms and adrenal gland size.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.

The conclusion is that early diagnosis and a multi-system treatment approach are crucial for managing PCOS and its associated health risks.

New treatments for male hypogonadism are effective and should be personalized.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Neurosteroids show promise for treating epilepsy and more research is needed.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

Topical JAK inhibitors may help treat some skin conditions but need more research.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.

Metabolic syndrome and PCOS are related but separate conditions, with metabolic syndrome increasing the risk of heart disease and diabetes.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

The current methods for diagnosing polycystic ovary syndrome are too vague and may lead to misdiagnosis and problems in research.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.

Baldness caused by male hormones in female-to-male transsexuals doesn't increase the risk of heart disease.

Androgens play a complex role in skin conditions like acne and hair loss in women, and normal blood levels don't always show true androgen status.