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Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.

People with common hair loss conditions may have a higher risk of heart disease and related health issues.

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Hydra can help understand human hair follicle microbiomes and develop new skin disease therapies.

Heat Shock Proteins are important in the development of Polycystic Ovarian Syndrome and could be targets for new treatments.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Hyperandrogenism increases heart disease risk in premenopausal women, but this risk is linked to obesity in postmenopausal women.

The book is a valuable reference on androgenic disorders for professionals but not suitable for laypeople or medical students.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Natural 5AR inhibitors effectively improve mild to moderate hair loss in men.

Plant extracts effectively reduce hair loss and increase growth, offering a safe alternative treatment.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

Women with PCOS have higher hair cortisol levels, which are linked to worse metabolic and inflammatory conditions.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

The document concludes that effectively managing PCOS requires a multifaceted approach.