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Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Long-term finasteride treatment reduces depression and brain issues in obese male rats.

Older people tend to have higher biotin levels, which are weakly linked to certain blood components and negatively linked to triglycerides; biotin should be checked in patients with high triglycerides or medication-related skin issues, and only supplemented if deficient. Vitamin D and folate deficiencies are linked to specific skin conditions.

The skin produces and processes hormones, affecting both local and overall body functions.

Probiotics show promise for health benefits but need more research to understand how they work.

Metabolic Syndrome is linked to several skin conditions, and stem cell therapy might help treat them.

Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.

Blocking YAP/TAZ could be a new way to treat skin cancer.

Autophagy prevents early aging and maintains lipid and pheromone balance in mouse glands.

HSPGs help control stem cell behavior, affecting hair growth and offering a target for hair loss treatments.

Finasteride-loaded proniosomes effectively promote hair growth in mice.

Genes and epigenetic changes are important in the development of Polycystic Ovary Syndrome.

The skin acts like an endocrine organ, producing hormones that affect various body functions and skin health, and understanding this can lead to new treatments.

More research is needed to understand how testosterone is maintained in adult males.

Different PCOS subgroups have similar metabolic features, but those without menstrual problems have milder issues.

Not getting enough minerals can lead to health problems and shorter lifespans.

Vitamin E affects liver metabolism, enhancing stress resistance, reducing blood clotting, and altering hormone processing.

9-cis-retinoic acid showed some effectiveness in treating AIDS-related Kaposi sarcoma but had significant side effects at higher doses.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

Low dose finasteride doesn't change lipid profile or metabolic parameters in mice.

There's no clear link between female pattern hair loss, insulin resistance, and metabolic syndrome.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Vitamin D deficiency is common in women with PCOS and linked to some metabolic problems, but not the main cause of their metabolic issues.

A new compound effectively inhibits human 5α-reductase 1.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.