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Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Dietary changes, including weight loss and a balanced diet, are important for managing PCOS, especially in overweight women.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Panax ginseng is generally safe with mild side effects and may have health benefits, but more research is needed.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

*Acorus calamus* has many medicinal benefits but needs more safety research.

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.

Quercetin may help with PCOS symptoms, but more research is needed.

Melatonin may help treat PCOS symptoms in rats.

Male hormones, or androgens, affect women's health in areas like mood and bone density, and hormone replacement therapy using antiandrogenic progestogens can improve mood disorders and alertness in menopausal women.

New drug delivery methods can make natural compounds more effective and stable.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Adrenal disorders can cause lasting brain and behavior issues in children.

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

New treatments for PCOS show promise, but no current medication treats all aspects of the condition.

Measuring reproductive hormones in brown bear hair could help identify their sex and reproductive state, but better collection methods or lab techniques are needed.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

A natural steroid in the body may protect against eye damage in glaucoma.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

Acanthosis nigricans is a skin condition that may indicate a higher risk for insulin resistance and type 2 diabetes, and more research is needed to understand and treat it.

Small changes in hormones can significantly impact health, showing the importance of sensitive testing for chemicals that disrupt hormones.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.

Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.