43 citations
,
August 2016 in “International Journal of Nanomedicine” This study found that a eupafolin nanoparticle delivery system improved water solubility and skin penetration, enhancing its antioxidant and anti-inflammatory effects against particulate matter-induced stress in skin cells.
42 citations
,
March 2018 in “PLOS Biology” This study found that autophagy plays a novel role in human hair growth, with altered autophagic flux during hair development phases influencing hair follicle behavior in a preclinical model.
42 citations
,
December 2015 in “International Journal of Clinical Pharmacology and Therapeutics” This study found that applying a novel 0.25% finasteride solution to the scalp can effectively reduce scalp DHT levels in men with androgenetic alopecia, potentially reducing systemic side-effects.
37 citations
,
February 2023 in “Gut Microbes” This study found that administering the gut bacterium Thauera sp. strain GDN1 to mice significantly reduced their serum androgen levels, indicating gut bacteria may influence androgen metabolism.
37 citations
,
May 2016 in “Scientific Reports” In this study, the researchers found that using a core-shell assembly of adipose-derived stem cells and dermal papilla cells reconstructed hair follicle cellular arrangements more effectively than mixed assemblies, enhancing hair formation in vivo.
36 citations
,
July 2014 in “Neuromuscular Disorders” This study investigated a patient with spinal and bulbar muscular atrophy who had 68 CAG repeats, revealing early onset and unique symptoms not previously documented in the condition.
36 citations
,
March 2014 in “Cell death and differentiation” This study indicated that abnormal Bmp signaling in β-catenin gain-of-function mutants is associated with anorectal malformations, shedding light on potential mechanisms underlying these congenital conditions.
36 citations
,
January 2006 in “Veterinary Dermatology” In this study, cyclosporin effectively controlled cases of granulomatous folliculitis, furunculosis, sebaceous adenitis in cats, and alopecia areata in a dog, positioning it as a promising alternative to glucocorticoids in veterinary dermatology.
35 citations
,
October 2017 in “Signal Transduction and Targeted Therapy” This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.
33 citations
,
December 2014 in “Journal of the European Academy of Dermatology and Venereology” This study found that lichen planus in Taiwanese patients is associated with several autoimmune diseases, including systemic lupus erythematosus, Sjögren's syndrome, and alopecia areata, with some gender-specific variations in associations.
33 citations
,
March 1996 in “Veterinary Quarterly” This report describes effective treatment of demodicosis in ferrets using amitraz, marking the first known cases in this species.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
32 citations
,
March 2019 in “Climacteric” This review examines the impact of spontaneous premature ovarian insufficiency on women's sexual function and highlights the need for a comprehensive, biopsychosocial approach to management, but presents no new clinical results.
31 citations
,
May 2021 in “Journal of endocrinological investigation” This study in Italy found that APS-1, a rare disorder, is associated with various AIRE gene mutations and most individuals have autoantibodies such as IFNωAbs, which are markers of the condition.
29 citations
,
June 2020 in “International Journal of Molecular Sciences” This review discusses the role of Notch signaling in skin diseases such as Hidradenitis Suppurativa and Psoriasis, but reports no new clinical results.
29 citations
,
November 2018 in “Journal of The European Academy of Dermatology and Venereology” This study found that anxiety-related traits significantly predict the impact of hair loss on quality of life across different alopecia types, with variations observed based on gender.
28 citations
,
March 2017 in “Endocrinology” In this study, the researchers found that vitamin D and calcium signaling in keratinocytes are essential for normal skin regeneration after wounding, with deficiencies significantly delaying wound closure and re-epithelialization in mice.
28 citations
,
April 2013 in “Fertility and Sterility” This study found that Caucasian and Asian women with PCOS in the San Francisco Bay Area had a similar prevalence of androgen excess, including hirsutism, across most measures.
27 citations
,
March 2018 in “Biomaterials” This study found that a cocktail of three proteins from embryonic skin can enable adult fibroblasts to regenerate hair follicles by altering gene expression and activating regenerative signaling pathways.
26 citations
,
May 2024 in “Molecular Neurodegeneration” This review assesses existing knowledge about the 17q21.31 inversion polymorphism, highlighting its genetic structure differences across ancestries, associations with various diseases, and implications for precision medicine and drug discovery.
26 citations
,
December 2020 in “International Journal of Molecular Sciences” This review explores current and emerging treatments for polycystic ovary syndrome, focusing on managing hyperandrogenism and cardiometabolic risk, but reports no new clinical results.
26 citations
,
May 2012 in “Pharmaceutical Development and Technology” PEVs effectively deliver minoxidil through skin.
25 citations
,
May 2004 in “Prenatal Diagnosis” This study suggests that prenatal genetic diagnosis of MELAS syndrome using amniotic cells may not reliably predict fetal outcomes due to phenotypic diversity observed in siblings with similar levels of mutant mtDNA.
24 citations
,
February 2021 in “Polymers” This study found that urchin-like Ag–Au bimetallic and Ag nanoparticle-decorated PAN mats showed significant antibacterial effects and potential for wound healing in in vitro and in vivo animal models.
24 citations
,
June 2018 in “Reviews in endocrine and metabolic disorders” This review discusses the epidemiology, clinical manifestations, and pathogenesis of autoimmune skin diseases and their associations with thyroid diseases, reporting no new clinical results.
23 citations
,
November 2017 in “Stem cell investigation” This study found that platelet lysate produced higher follicular regeneration in hair restoration surgeries compared to activated PRP and saline, with significant gains in both follicular unit and hair density.
22 citations
,
March 2017 in “Journal of the Formosan Medical Association” This report presents the Taiwanese Dermatological Association's 2016 consensus on defining and managing skin toxicities from EGFR-TKI treatments, providing comprehensive guidelines for clinicians in Taiwan.
22 citations
,
August 2014 in “Clinical endocrinology” This study suggests that the use of finasteride for benign prostate hyperplasia may increase the risk of osteoporosis diagnosis, particularly at higher doses.
22 citations
,
June 2017 in “Stem cell reports” This study found that PTEN regulates the number and genomic stability of hair follicle stem cells in the skin, with its deficiency leading to increased stem cell accumulation and senescence through interactions with BMAL1 and BMI-1.
20 citations
,
February 2021 in “Frontiers in Pharmacology” This study identified key natural medicinal materials used in traditional Chinese medicine across Taiwan for inducing lactation, highlighting Angelica sinensis as a primary core component in galactogenous prescriptions.