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Some herbal therapies may help with skin conditions, but more research is needed to confirm their safety and effectiveness.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

High lactate dehydrogenase activity is not necessary for the growth of squamous cell carcinoma.

TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.

Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.

Smad4 is important for healthy hair follicles because it helps produce a protein needed for hair to stick together and grow.

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

Different sPLA2 enzymes affect immunity, skin and hair health, reproduction, and may be potential targets for therapy.

The study found stem cells in minor salivary glands that can differentiate and are involved in tumor formation when exposed to tobacco.

Indian Hedgehog helps control skin cell growth and protects against aggressive skin cancer.

sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.

Putting α-methylspermidine on mouse skin can start hair growth.

Some topical treatments like corticosteroids and vitamin D analogues are effective for scalp psoriasis, but more long-term data is needed.

Genetic mutation and carcinogen treatment are both needed for skin cancer to develop in these specific mice.

The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

Key genes linked to hair growth and cancer were identified in hairless mice.

Indian Gooseberry has potential for cancer prevention and treatment and promotes hair growth.

The study found that giant pandas have more melanin in black hair follicles than white, with gene expression differences that could affect hair color and skin health.

CD4+ skin cells may be precursors to basal cell carcinoma.

The document concludes that identifying the specific cells where skin cancers begin is important for creating better prevention, detection, and treatment methods.

Lipids may help treat hair loss by promoting hair growth through the HIF-1 pathway.