69 citations
,
January 2009 in “Advances in Materials Science and Engineering” This study demonstrated that keratin can be effectively extracted from wool using alkaline solutions and that the extracted keratin maintains reactivity similar to that from other low-value sources like cattle hair.
67 citations
,
May 2019 in “British Journal of Dermatology” In this study, newly diagnosed women with mycosis fungoides or Sézary syndrome and those with alopecia experienced significantly poorer health-related quality of life.
66 citations
,
June 2006 in “Journal of The American Academy of Dermatology” This study found that long-term finasteride treatment in men with androgenetic alopecia significantly increased hair weight and count compared to placebo over nearly four years.
66 citations
,
April 2002 in “Journal of The American Academy of Dermatology” In this study, finasteride, 1 mg daily, significantly increased hair weight more than hair count in men with androgenetic alopecia, indicating additional factors like hair growth rate and thickness may contribute to its effectiveness.
64 citations
,
April 1992 in “Differentiation” This study identified Sciellin, a new protein precursor to the cornified envelope in keratinocytes, with unique solubility properties hinting at its potential role in envelope assembly.
62 citations
,
April 2013 in “Steroids” This review discusses the age-related diagnostic challenges and comorbidities of polycystic ovarian syndrome and provides no new clinical findings; the authors emphasize the role of obesity in insulin resistance among affected women.
62 citations
,
December 1966 in “Endocrinology” This study observed that injecting mice with α-MSH resulted in black hair regrowth in shaved and plucked areas, suggesting a potential link to the agent darkening hair in animals with a specific pituitary tumor.
52 citations
,
April 2012 in “Journal of Investigative Dermatology” This study found that KRTAP2 proteins predominantly express in the hair shaft cortex of humans, interact with hair keratins, and play crucial roles in hair shaft keratinization.
51 citations
,
January 2012 in “Annals of Dermatology” This review discusses characteristics of androgenetic alopecia in Asian patients and includes algorithmic management guidelines, but reports no new clinical findings.
51 citations
,
January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a novel keratin-associated protein, KAP24.1, which is specifically expressed in the human scalp and located in the hair cuticle.
50 citations
,
September 2016 in “The Journal of Clinical Endocrinology and Metabolism” This study found no evidence of androgen deficiency or decreased peripheral androgen action in men with persistent sexual symptoms after finasteride use, but identified links to depressed mood and abnormal brain function.
50 citations
,
February 2013 in “BMC evolutionary biology” This study found that the Hr gene loss and positive selection for the FGF5 gene in cetaceans likely contributed to hair loss as these animals adapted to aquatic environments.
50 citations
,
July 2008 in “British Journal of Dermatology” 49 citations
,
February 2014 in “Clinical Cosmetic and Investigational Dermatology” This review discusses the diagnostic and therapeutic approaches to furunculosis, emphasizing the importance of hygiene and microbiological testing to prevent and manage recurrent infections, and reports no new clinical results.
49 citations
,
July 2009 in “Fitoterapia” This study found that C. obtusa oils promoted hair growth in shaved mice and increased the expression of a hair growth regulator, VEGF, in a cell line.
48 citations
,
April 2024 in “Nature Communications” This study demonstrated that a mechanical-assisted post-bioprinting strategy significantly increased cell numbers and enhanced regenerative capabilities in hollow hydrogel-based scaffolds for bone defect repair in vivo.
48 citations
,
January 2018 in “Scientific Reports” This pilot study found that hair metabolome analysis may help differentiate pregnancy complications from healthy pregnancies by revealing significant metabolite differences between trimesters.
48 citations
,
January 2018 in “Stem Cells International” This review discusses autologous tissue engineering strategies and skin-derived stem cell transplantation products, noting clinical challenges and highlighting ongoing trial activities, without reporting new clinical outcomes.
48 citations
,
February 2010 in “Molecular biology reports” This study found that KAP7.1 and KAP8.2 genes were significantly more expressed in secondary hair follicles than primary follicles, suggesting their role in regulating cashmere fiber diameter.
47 citations
,
January 2017 in “RSC Advances” Keratin peptides can change hair shape gently without harsh chemicals.
45 citations
,
August 1992 in “PubMed” In this study, researchers found that changes in the extracellular matrix components, particularly fibronectin, laminin, and type IV collagen, during the rat vibrissa follicle growth cycle, suggest dynamic remodeling related to dermal-epidermal signaling.
41 citations
,
June 2013 in “PLOS ONE” This study demonstrated that engineered skin substitutes using human keratinocytes and murine dermal papilla cells can develop pigmented hairs without sebaceous glands, suggesting separate pathways for hair development and eruption.
41 citations
,
May 2005 in “International Journal of Cosmetic Science” This study observed that in Japanese females, hair lipid composition showed significant correlations, suggesting CH and CERs may act as a barrier against sebum-derived lipids.
40 citations
,
November 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that different melanocyte subpopulations in hair follicles have varying patterns of apoptosis and survival during the catagen phase, which may inform models for modulating melanocyte behavior in vivo.
40 citations
,
February 1994 in “Journal of Investigative Dermatology” 35 citations
,
March 2010 in “British journal of dermatology/British journal of dermatology, Supplement” This study demonstrates that mouse eyelashes can effectively model human eyelash growth to analyze morphology, development, and the effects of growth-stimulatory agents like bimatoprost.
34 citations
,
January 2008 in “International Review of Neurobiology” This review discusses the interplay between epilepsy and reproductive endocrine disorders, examining the factors involved and emphasizing the importance of monitoring but reports no new research findings.
34 citations
,
September 2007 in “Experimental Dermatology” This study found that the outer protein layer of Merino wool is rich in sulfur-containing proteins similar to those found in both sheep wool and human hair.
32 citations
,
February 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the cloning and sequencing of two type II hair-specific keratin genes, ghHb1 and ghHb6, located on chromosome 12q13, which are expressed during hair growth.
31 citations
,
December 2012 in “British Journal of Dermatology” This study found that as Korean women age, their hair density, diameter, tensile strength, and lustre decline, while grey hair ratio and certain sterol contents increase, suggesting unique ageing features compared to women in other countries.