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      Human Skin Stem Cells and the Aging Process

      research Human skin stem cells and the ageing process

      143 citations , September 2008 in “Experimental gerontology”
      This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
      Transfollicular Drug Delivery: Is It a Reality?

      research Transfollicular drug delivery—Is it a reality?

      141 citations , November 2005 in “International journal of pharmaceutics”
      This review examines the role of hair follicles and sebaceous glands in percutaneous drug delivery but does not report new clinical results; it calls for further exploration of follicle-targeting therapies.
      Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

      research Hairless triggers reactivation of hair growth by promoting Wnt signaling

      137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”
      In this study, researchers found that transgenic expression of the Hairless gene in keratinocytes can restore hair follicle regeneration in Hr-deficient mice by repressing Wise, a modulator of Wnt signaling.
      EEMCO Guidance for the In Vivo Assessment of Skin Greasiness

      research EEMCO Guidance for the in vivo Assessment of Skin Greasiness

      137 citations , January 2000 in “Skin Pharmacology and Physiology”
      This review outlines the factors affecting skin greasiness and sebum production, highlighting measurement challenges but reports no new clinical findings; further research may guide sebosuppressive treatments for acne.
      The Role of Vitamins and Minerals in Hair Loss: A Review

      research The Role of Vitamins and Minerals in Hair Loss: A Review

      134 citations , December 2018 in “Dermatology and Therapy”
      This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
      Androgenetic Alopecia and Microinflammation

      research Androgenetic alopecia and microinflammation

      131 citations , August 2000 in “International Journal of Dermatology”
      Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
      Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

      research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

      130 citations , January 1994 in “Differentiation”
      In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
      Androgen Actions on the Human Hair Follicle: Perspectives

      research Androgen actions on the human hair follicle: perspectives

      115 citations , September 2012 in “Experimental Dermatology”
      This article reviews the molecular mechanisms involved in androgenetic alopecia and the androgen's paradoxical role in hair growth, but reports no new experimental findings.
      Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      research Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      112 citations , November 2023 in “Nano-Micro Letters”
      This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
      Group-ICA Model Order Highlights Patterns of Functional Brain Connectivity

      research Group-ICA Model Order Highlights Patterns of Functional Brain Connectivity

      109 citations , January 2011 in “Frontiers in Systems Neuroscience”
      The researchers reported that differences in brain functional connectivity between unmedicated seasonal affective disorder patients and healthy controls vary with ICA model order, peaking in volume at model order 70.
      Development and Homeostasis of the Sebaceous Gland

      research Development and homeostasis of the sebaceous gland

      107 citations , August 2012 in “Seminars in Cell & Developmental Biology”
      This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.
      Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

      research Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

      102 citations , December 2017 in “˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings”
      This review discusses the role of immune privilege collapse in the pathogenesis of alopecia areata, emphasizing the potential for therapeutic manipulation of hair bulb immune privilege to offer new treatment options, and reports no new results.
      Congenital Adrenal Hyperplasia: Comprehensive Overview and Clinical Management

      research Congenital Adrenal Hyperplasia

      100 citations , May 2011 in “Journal of Pediatric and Adolescent Gynecology”
      This review covers the pathophysiology, diagnosis, and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency and reports no new findings.
      Acne-Associated Syndromes: Models for Better Understanding of Acne Pathogenesis

      research Acne-associated syndromes: models for better understanding of acne pathogenesis

      99 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”
      This article discusses the association of acne with various systemic diseases, emphasizing the role of androgen steroids, insulin resistance, and inflammation in acne pathogenesis, but it reports no new clinical results.
      Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function

      research Beyond acne: Current aspects of sebaceous gland biology and function

      97 citations , September 2016 in “Reviews in Endocrine and Metabolic Disorders”
      This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.
      Endocrine Control of Benign Prostatic Hyperplasia

      research Endocrine control of benign prostatic hyperplasia

      97 citations , April 2016 in “Andrology”
      This review discusses the etio-pathogenetic factors in benign prostatic hyperplasia and their role in the development of lower urinary tract symptoms but reports no new research findings.
      Protection Against Chemotherapy-Induced Alopecia

      research Protection Against Chemotherapy-Induced Alopecia

      97 citations , September 2006 in “Pharmaceutical Research”
      This review discusses advances in protecting against chemotherapy-induced alopecia and reports no new clinical results; calcitriol and cyclosporine A emerged as promising agents in animal models with broader efficacy across multiple chemotherapy drugs.
      Hormonal Therapy for Acne

      research Hormonal Therapy for Acne

      96 citations , September 2008 in “Seminars in Cutaneous Medicine and Surgery”
      This review discusses the hormonal influences on acne's development in women and the therapeutic potential of hormonal treatments, but it reports no new clinical results.
      Physiological Changes in the Skin During Pregnancy

      research Physiological changes in the skin during pregnancy

      96 citations , January 1997 in “Clinics in Dermatology”
      This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
      Delivery and Targeting of Nanoparticles into Hair Follicles

      research Delivery and targeting of nanoparticles into hair follicles

      94 citations , September 2014 in “Therapeutic Delivery”
      This review describes recent advances in using nanoparticles for drug delivery to hair follicles, with potential applications in treating skin diseases such as alopecia and acne, but reports no new findings.
      Male Pattern Alopecia: A Histopathologic and Histochemical Study

      research Male Pattern Alopecia A Histopathologic and Histochemical Study

      94 citations , August 1975 in “Journal of Cutaneous Pathology”
      In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.