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Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Blocking BACE1 and BACE2 enzymes causes hair color loss in mice.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

The guide explains how to study human and mouse sebaceous glands using various staining and imaging techniques, and emphasizes the need for standardized assessment methods.

FOXN1 gene variants cause low T cells and immune issues from birth.

Different harmful mutations in the CDH3 gene cause HJMD, but symptoms vary among individuals.

Skin tumor regression is helped by retinoic acid signaling blocking Wnt signaling.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Patients with acanthosis nigricans often have insulin resistance and signs of increased male hormones, but treatment targeting these male hormones is generally ineffective.

Fat cells are important for tissue repair and stem cell support in various body parts.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.

New treatments for immune disorders caused by FOXN1 deficiency are promising.

Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

Certain medications and patient factors increase the risk of Intraoperative Floppy Iris Syndrome during cataract surgery, but with careful planning and technique adjustments, complications can be minimized.

Cell-based therapies show promise for treating Limbal Stem Cell Deficiency but need more research.

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.

The skin and thymus develop similarly to protect and support immunity.

Skin stem cells are maintained by signals from nearby cells and vary in their ability to renew and mature.

African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.

Bimatoprost can cause longer, thicker, darker eyelashes and eyebrows.

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.