5 citations
,
January 2025 in “Burns & Trauma” This study suggests that activating the PPARs/SHH-mitochondrial axis may enhance diabetic wound healing by improving endothelial cell metabolism and angiogenesis, indicating potential for PPAR agonists in treating diabetic foot ulcers.
This study found that targeting peroxisomal dysfunction with catalytic nanozymes enhanced hair follicle regeneration and outperformed minoxidil in promoting hair growth and maintaining efficacy in immunodeficient mice.
August 2025 in “Frontiers in Immunology” This study found that patients with primary cicatricial alopecia are at higher risk of developing various comorbidities, including systemic lupus erythematosus, hypothyroidism, and dermatological conditions, compared to controls.
March 2025 in “International Journal of Molecular Sciences” This study analyzed proteomic changes in Jiangnan cashmere goats' secondary hair follicles and found that the PLIN2 gene significantly impacts hair follicle growth cycles by affecting dermal papilla cell proliferation, offering insights into breeding strategies to enhance cashmere yield.
November 2023 in “Journal of Investigative Dermatology” This research investigated immune cell involvement in various types of inflammatory alopecia by analyzing gene expression data from scalp samples, revealing distinct cellular changes in conditions like Alopecia Areata, Frontal Fibrosing Alopecia, Lichen Planopilaris, and Central Centrifugal Cicatricial Alopecia, which may inform future therapeutic targets.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that CD200R expression is significantly reduced in an experimental mouse model of scarring alopecia, suggesting a potential role for this pathway in immune regulation and hair follicle protection.
July 2022 in “JEADV Clinical Practice” This review discusses the classification of lichen planopilaris and its subtypes under the proposed term "lichenoid alopecias," suggesting they exist along a clinical and histological spectrum.
July 2022 in “Journal of Investigative Dermatology” This study suggests that distinct alopecia scoring systems measure percent hair loss as a common underlying feature, with strong correlations observed between different types of hair loss assessments.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that fibrosis-associated trochanters in central centrifugal cicatricial alopecia are enriched with hair follicle stem cells and may indicate a disrupted stem cell niche contributing to scarring.
3 citations
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July 2023 in “International journal of molecular sciences” This review discusses the association between emotional stress-related neuropeptides and the pathogenesis of alopecia areata, reporting no new experimental findings.
20 citations
,
January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” This review discusses lysophosphatidic acid's role in neuropathic pain and cholestatic itch, highlighting its complex signaling pathways, but reports no new clinical results.
12 citations
,
January 2022 in “International Journal of Clinical Practice” This study found that women with PCOS, especially those who are obese, showed higher oxidative stress and decreased antioxidant levels, correlating with metabolic syndrome and cardiovascular disease risk factors.
5 citations
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August 2019 in “International Journal of Women's Dermatology” This article discusses various types of alopecia more common in African-American individuals and reports no clinical results; it highlights the importance of recognizing and differentiating these subtypes for diagnosis and treatment.
2 citations
,
February 2021 in “The Journal of clinical and aesthetic dermatology” This review examines the various potential causes of bitemporal hair loss, emphasizing the importance of prompt diagnosis to prevent further hair loss in scarring conditions; it reports no new clinical results.
2 citations
,
January 2023 in “Journal of The American Academy of Dermatology” This study investigated the use of scalp biopsies for diagnosing and managing alopecia in Black women, focusing on distribution, prevalence, and biopsy outcomes, but did not report new clinical results.
1 citations
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March 2025 in “Journal of Investigative Dermatology” Metabolic issues may trigger lymphocytic cicatricial alopecia, and treatments targeting these issues could help.
1 citations
,
April 2019 in “Endokrynologia Polska” This review discusses lifestyle interventions to manage weight and reduce metabolic consequences in women with PCOS but reports no new clinical results, highlighting the need for more randomized studies.
January 2023 in “Dermatologic Therapy” In this randomized controlled trial, the nutritional supplement PPT5 α was associated with increased terminal hair percentages and improved self-assessed hair parameters in women with early-stage androgenetic alopecia.
May 2020 in “Plastic and Aesthetic Research” This abstract describes alternative facelift techniques that utilize endoscopic methods to work on the subperiosteal plane, potentially reducing the risk of facial nerve injury and allowing for integrated beautification and rejuvenation strategies, but it reports no new clinical findings.
March 2026 in “Adipocyte” This study identified transcription elongation as a crucial regulatory factor in adipocyte cell fate, showing that the elongation factors Spt4 and Spt6 are essential for proper adipogenic differentiation by aiding RNA polymerase II progression through key adipogenic genes.
January 2024 in “Journal of the American Academy of Dermatology” Biopsies matched initial diagnoses in 76.6% of black women with alopecia and led to treatment changes in 44% of cases.
September 2023 in “JEADV Clinical Practice” This study reviewed existing literature and found that androgenic alopecia may be associated with cardiovascular risk factors, while evidence for alopecia areata and cicatricial alopecias is limited and sometimes contradictory.
4 citations
,
May 2012 in “Journal of Investigative Dermatology” This symposium discussed the role of lipids, inflammation, and stem cells in cicatricial alopecia but reports no new research findings; it highlights lipid pathways as significant in these hair disorders.
219 citations
,
January 2006 in “Drug Metabolism Reviews” This review discusses how dehydroepiandrosterone (DHEA) may exert its biological effects through multiple receptors and reports no new clinical results.
98 citations
,
May 2010 in “British Journal of Dermatology” This document discusses the British Association of Dermatologists' current perspective on isotretinoin, focusing on its known side effects, prescribing requirements, teratogenic risks, and the contentious link to mood changes, reporting no new research findings.
88 citations
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August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
63 citations
,
February 2017 in “ACS biomaterials science & engineering” In this study, polydopamine emerged as a safe and effective alternative to traditional hair dyes like PPD for dyeing gray hair permanently, showing resistance to detergents and causing less toxicity and hair loss in mice.
40 citations
,
August 2021 in “JAAD international” This review found that teledermatology was significantly used during the COVID-19 pandemic, particularly for managing common ambulatory dermatoses like acne and eczema.
21 citations
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November 2019 in “Molecular & Cellular Proteomics” This study found that citrullinated proteins, which are implicated in rheumatoid arthritis, were abundant in outer membrane vesicles from Porphyromonas gingivalis but nearly absent in mutants, validating their approach to citrullinated peptide identification.
12 citations
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November 2012 in “BioMolecular Concepts” This review discusses the diverse roles of PPARβ/δ in skin health and disease, including its involvement in skin wound healing and inflammatory skin conditions, without presenting new experimental results.