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p14ARF and p16Ink4a cause hair follicle stem cell aging and dysfunction.

The study reported that reducing finasteride particle size significantly improved its cellular permeation through prostate epithelial cells, though it had a lesser impact on systemic pharmacokinetics and tissue distribution in rats.

This review explores regenerative treatment options for non-scarring alopecia, with a focus on the potential of mesenchymal stem cells for hair regrowth, but it reports no new clinical results.

In this study of patients with Androgenic Alopecia, micro-grafts containing HD-AFSCs resulted in significantly improved hair density and follicle count over 11 months compared to a saline solution, suggesting a potential alternative therapy for hair regrowth.

In this study, in vitro and in vivo models showed that chrysin enhanced the efficacy of docetaxel and reduced its adverse effects in non–small cell lung cancer treatment.

This study explores the potential roles of exosomes in anti-aging applications, highlighting their ability to modulate inflammation, promote tissue regeneration, and transfer bioactive molecules to rejuvenate aging tissues and reverse cellular dysfunction.

In this review, researchers discussed the anti-inflammatory and immunomodulatory properties of metformin and hypothesized that its topical application could benefit those with alopecia areata, given its effects on immune pathways, hair regrowth, and autoimmune disease management.

In this clinical study of 98 patients with focal alopecia, combined laser therapy, which included laser plasma therapy and percutaneous laser irradiation of blood, was reported to alleviate inflammation, promote hair growth, and restore trace elements in affected areas.

This review synthesizes preclinical evidence suggesting that Centella asiatica may extend healthspan by modulating aging hallmarks, enhancing DNA repair, improving mitochondrial function, and reducing inflammation and oxidative stress, potentially paving the way for future gerotherapeutic strategies.

This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.

This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.

In this review, the authors explored the diverse roles of fibroblasts in wound healing, suggesting that understanding their complexity could lead to better insights into wound pathologies and the development of new treatments.

This study found that patients with alopecia areata receiving combined therapy showed a significant reduction in proinflammatory cytokines and circulating immune complexes, along with increased IL-10 levels and phagocytic activity, suggesting an immunomodulatory effect that reduces inflammation and restores immune balance.

This study highlights recent biological and technological strategies in anti-aging research aimed at delaying aging and related diseases, improving skin healing, and potentially restoring hair growth.

This study found that inhibiting NF-κB Essential Modulator (NEMO) in senescent murine dermal fibroblasts successfully reduced key factors associated with the senescence associated secretory phenotype (SASP), highlighting its potential as a therapeutic target for aging-related diseases.

This research presents a comprehensive workflow for producing EMA-compliant autologous keratinocyte-based therapies for wound healing and explores miRNA-mediated regulations in human keratinocytes and adipose-derived mesenchymal stem cells.

Sex and race affect immune responses and treatment outcomes in Hidradenitis suppurativa.

In this study, women with androgenetic alopecia underwent stem cell treatment, which led to significant improvements in sexual arousal and satisfaction, psychological health, and environmental quality of life, but not in physical health or social relationships after six months.

This narrative review reports that well-selected plant extracts and their active compounds may improve hair health by promoting hair growth and preventing hair loss, potentially aiding in developing targeted therapies for alopecia.

This review discusses recent advances in understanding hair growth mechanisms and reviews current and emerging therapies, but it presents no new clinical results.

This article discusses the role of regulatory T cells in alopecia areata, where their deficiency in hair follicles may lead to impaired local immunity and suggests potential therapies like CAR-T reg cells and low-dose IL-2 to alleviate autoimmunity and promote hair regeneration in affected individuals.

In this study, Wnt-3a was found to play an important role in partially maintaining and expanding epithelial skin stem cells in vitro, suggesting potential for in vitro stem cell culture without feeder cells.

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

This review compiles epidemiological data on actinic keratoses and suggests promoting strategies like early diagnosis and photoprotection to prevent progression to skin cancer, but it reports no new clinical findings.

This review covers the use of photobiomodulation devices for hair regrowth in various types of alopecia and reports no new clinical results.

This study reports that dynamic interactions between stem cells and their niche, influenced by macro-environmental factors, regulate regenerative behavior in integument pattern formation.

This review examines the use of platelet-rich plasma in aesthetic medicine and reports no new clinical results, highlighting the need for further research into its efficacy and safety.

The review concluded that better studies are needed to prove if Low-Level Laser Therapy devices for hair growth really work.

This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.

Laser and light therapies can help regrow hair but need more research for best results.