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Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Sebocytes play a key role in controlling androgen levels in human skin.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Bone Morphogenetic Proteins (BMPs) help control skin health, hair growth, and color, and could potentially be used to treat skin and hair disorders.

Some medicinal plants can help heal wounds and may lead to new treatments.

Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.

Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Understanding hair growth involves complex interactions between molecules and could help treat hair disorders.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Laser device increases hair density, safe for treating hair loss in men and women.

Aging causes skin stem cells to work less effectively.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Stress can stop hair growth in mice, and treatments can reverse this effect.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.