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Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

Dermal EZH2 controls skin cell growth and differentiation in mice.

The document is a detailed medical reference on skin and genetic disorders.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.

Acitretin is effective for severe psoriasis and can be used long-term due to no immunosuppression, but must be carefully monitored for side effects and is not for pregnant women.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

The document concludes that recognizing and properly diagnosing lipodystrophy syndromes is crucial for effective management and treatment.

Adipokines affect skin health and could be targeted for treating skin diseases.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Proteomics combined with other technologies can lead to a better understanding of skin diseases.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

Vitamin A toxicity can cause severe health issues and may require a liver transplant if other treatments fail.

Researchers found 617 genes that behave differently in cashmere goat hair follicles, which could help understand hair growth.

Retinoids are effective for skin conditions like severe acne and psoriasis but must be used with caution due to potential side effects and risks during pregnancy.

Women with idiopathic hirsutism and PCOS have higher RBP4 levels, and PCOS is linked to greater insulin resistance; weight management may help both conditions.

Women with PCOS have similar levels of certain proteins compared to women without PCOS, and these proteins don't independently cause PCOS.

Rosiglitazone may be better than metformin for insulin resistance in PCOS, but more research is needed on certain biomarkers.

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

Retinol may affect immune responses in people with frequent skin boils.

Serenoa repens and N-acetyl glucosamine/milk proteins complex may help with hair growth and prevent hair loss.

Different parts of the body's fat tissue have unique cell types and characteristics, which could help treat chronic wounds.

Many popular skincare products claim to prevent aging but lack strong evidence to prove their effectiveness and safety.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Researchers found a way to grow cashmere goat hair cells in a lab and discovered that certain conditions improve these cells' growth and characteristics.