research Susan Lee Lindquist (1949–2016)—Pioneer in the Study of Cellular Protein Folding and Disease
Susan Lee Lindquist was a pioneering biologist who made significant contributions to understanding protein folding and its role in disease.
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research Hormesis And Medicine: Biphasic Dose-Response Relationship
Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
research Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes
Cysteine helps maintain keratin production in skin cells even when iron is low.
research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis
Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.
research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
research Impact of Taxol on Dermal Papilla Cells: A Proteomics and Bioinformatics Analysis
Taxol damages hair growth cells, causing hair loss.
research The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation
Finasteride in male rats causes liver and metabolic issues in their offspring.
research Endoplasmic Reticulum in Health and Disease: The 12th International Calreticulin Workshop, Delphi, Greece
The workshop discussed the role of a protein called calreticulin in health and disease, its potential as a treatment target, and its possible use as a disease marker.
research SOX9 in Organogenesis: Shared and Unique Transcriptional Functions
SOX9 is essential for the development of various organs and hair follicles.
research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder
Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.
research Dysregulation of Grainyhead-Like 3 Expression Causes Widespread Developmental Defects
Not having enough or having too much of the protein Grainyhead-like 3 leads to various developmental problems.
research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease
Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.
research Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits
The KRTAP21-1 gene affects wool yield and can help improve wool production.
research Cryogelation of Human Hair Keratins
Human hair keratins can be turned into useful 3D biomedical scaffolds through a freeze-thaw process.
research Dermal Niche Signaling and Epidermal Stem Cells
Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
research Proteomic Analysis of Balding and Non-Balding Mesenchyme-Derived Dermal Papilla Cells from Androgenetic Alopecia Patients Using Online Two-Dimensional Reversed Phase-Reversed Phase LC-MS/MS
Found different proteins in balding and non-balding cells, giving insight into hair loss causes.
research The Mean Staple Length of Wool Fiber Is Associated with Variation in the Ovine Keratin-Associated Protein 21-2 Gene
The KRTAP21-2 gene affects wool length and quality in sheep.
research Multi-Ancestry Tandem Repeat Association Study of Hair Color Using Exome-Wide Sequencing
Tandem repeats significantly influence hair color, especially darker shades, across different ancestries.
research Genome-Wide Association Study in Japanese Females Identifies Fifteen Novel Skin-Related Trait Associations
Researchers found 15 new genetic links to skin traits in Japanese women.
research Structures of Get3D Reveal a Distinct Architecture Associated with the Emergence of Photosynthesis
Get3d protein helps maintain photosynthesis in plants and photosynthetic bacteria.
research Root Hair Defective Six-Like 4 (RSL4) Promotes Root Hair Elongation by Transcriptionally Regulating the Expression of Genes Required for Cell Growth
The protein RSL4 is crucial for making root hairs longer by controlling genes related to cell growth.
research CBL1-CIPK26-Mediated Phosphorylation Enhances Activity of the NADPH Oxidase RBOHC, but Is Dispensable for Root Hair Growth
A specific protein complex increases the activity of a plant enzyme, but this action is not required for plant root hair growth.
research Quantifying the Effects of Repeated Dyeing: Morphological, Mechanical, and Chemical Changes in Human Hair Fibers
Repeated hair dyeing significantly damages hair.
research A Hairy Situation: PADIs in Regeneration and Alopecia
Enzymes called PADIs play a key role in hair growth and loss.
research Special Collection on Inward Rectifying Potassium Channels
Inward rectifier potassium channels are important in many body functions and diseases, and could be potential drug targets.
research The Role of Heat Shock Proteins in the Pathogenesis of Polycystic Ovarian Syndrome: A Review of the Literature
Heat Shock Proteins are important in the development of Polycystic Ovarian Syndrome and could be targets for new treatments.
research Hair for Brain Trade-Off: A Metabolic Bypass for Encephalization
Human hair loss may have evolved to help increase brain size.
research Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis?
Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.
research Editor's Evaluation: Plant Trans-Golgi Network/Early Endosome pH Regulation Requires Cation Chloride Cotransporter (CCC1)
CCC1 is crucial for pH balance in plant cells, affecting growth and stress tolerance.
research Mineral Deficiencies: A Root Cause for Reduced Longevity in Mammals
Not getting enough minerals can lead to health problems and shorter lifespans.