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HSD11b1 affects skin nerves and increases non-histaminergic itch.

The document concludes that individualized treatments for hair issues are effective, certain hair changes can indicate neurocutaneous diseases, specific lotions improve skin health, laser hair removal works but needs more study on long-term effects, men's cosmetics are diverse, peeling is effective but can have side effects, and facial pigmentation is often due to overactive skin cells.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Androgens can both increase and decrease hair growth in different parts of the body.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Some medicinal plants can help heal wounds and may lead to new treatments.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Mannosylerythritol lipids are good for skin and hair care products.

Animal models have helped understand hair loss from alopecia areata and find new treatments.

White lupin uses specific genes to grow root hairs and access phosphorus when it's scarce.

Muscles and nerves that cause goosebumps also help control hair growth.

Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.

Fat tissue cells are a promising option for healing various diseases, but more research is needed to ensure they are safe and effective.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.

Korean Red Ginseng has beneficial components that help with stress, immunity, fatigue, memory, blood flow, and disease protection.

Red ginseng may improve immunity, fatigue, memory, blood circulation, and menopausal symptoms, and is generally safe to consume.