August 2026 in “Molecules” This study found that Eucommia ulmoides bark extract shows potential antioxidant and hair follicle-support properties in vitro and in vivo, but further validation is needed to confirm these effects.
June 2023 in “Dermatopathology” In this case report, researchers described a unique skin lesion in a 55-year-old woman, identifying it as folliculosebaceous cystic hamartoma with an unusual combination of spindle cell lipomatous and neural components, which had not been previously documented in such cases.
October 2024 in “Applied Sciences” In this study, tubular 3D bioprinted structures made from sodium alginate and gelatin, containing NIH/3T3 fibroblast cells, demonstrated the ability for cell growth and network formation over 6 weeks, although structural tensile strength decreased with cell growth and polymer degradation.
February 2026 in “Preprints.org” In this study, extracellular vesicles from Saccharomyces cerevisiae demonstrated multifunctional bioactivity, enhancing cell proliferation and migration, reducing inflammation, and promoting collagen gene expression in hair follicle–related cells.
7 citations
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August 2020 in “Plastic and reconstructive surgery. Global open” In this study, QR 678 and QR 678 Neo formulations containing growth factors and peptides were found to be safe in vitro and promoted hair growth in vivo in an animal model, suggesting their potential as treatments for alopecia, including secondary alopecia post-chemotherapy.
2 citations
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June 2012 in “American Journal of Dermatopathology” This case study describes a rare cutaneous follicular hybrid cyst intimately associated with syringocystadenoma papilliferum, proposing a potential relationship with the infrainfundibulum based on keratin expression.
September 2024 in “International Journal of Molecular Sciences” This study found that hot water extract of Hydrangea serrata leaf and hydrangenol promoted hair growth by enhancing 5α-reductase inhibitory activity, stimulating dermal papilla cell growth, and exhibiting anti-inflammatory and anti-androgenic effects in cell cultures, mice, and human skin organoid models.
March 2026 in “Molecules” This review reports that Dang Gui (Radix Angelica sinensis) possesses bidirectional immunoregulatory effects, enhancing immune cell proliferation and function, and may benefit immune-related diseases such as cancer and anemia. It also evaluates regulatory and safety aspects, aiming to guide future research and clinical use.
November 2022 in “Cosmetics” This study observed that SY red pericarp rice extract promotes hair growth, inhibits 5α-reductase, and enhances hair regeneration in mice, with the extract being safe from cytotoxicity and irritation, indicating its potential as a natural hair growth promoter.
May 2023 in “Frontiers in Immunology” This article discusses the role of regulatory T cells in alopecia areata, where their deficiency in hair follicles may lead to impaired local immunity and suggests potential therapies like CAR-T reg cells and low-dose IL-2 to alleviate autoimmunity and promote hair regeneration in affected individuals.
September 2023 in “Molecular frontiers journal” This paper highlights the growing interest in exosomes for their therapeutic and diagnostic potential in cosmetic dermatology, noting their roles in skin rejuvenation, postprocedural care, and antiaging treatments.
65 citations
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October 1988 in “Clinics in dermatology” This study found that dermal papilla cells may play a critical role in hair follicle development and cycling by promoting epidermal proliferation and potentially mediating systemic factors that influence follicle behavior.
32 citations
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September 2018 in “Journal of pharmaceutical sciences” This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.
211 citations
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February 1994 in “Proceedings of the National Academy of Sciences” This study found that overexpression of parathyroid hormone-related peptide in transgenic mice skin disrupted normal hair follicle development, suggesting a role for the peptide in the early stages of follicle formation.
January 2026 in “Journal of Clinical Case Studies” This article discusses the potential of copper tripeptide (GHK-Cu) to support collagen synthesis and antioxidant activity in the context of androgenetic alopecia but reports no clinical results.
April 2018 in “Journal of Investigative Dermatology” This study found that inhibiting NF-κB Essential Modulator (NEMO) in senescent murine dermal fibroblasts successfully reduced key factors associated with the senescence associated secretory phenotype (SASP), highlighting its potential as a therapeutic target for aging-related diseases.
11 citations
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August 2021 in “Aging” This study found that TGF-β2 may enhance collagen expression and spheroid formation in human dermal papilla cells, which could improve their hair inductivity and maintenance.
2 citations
,
September 2025 in “International Journal of Nanomedicine” This review discusses the roles of extracellular vesicles in skin health and disease and reports no clinical results; the authors highlight potential therapeutic uses and call for more research.
August 2023 in “Molecules and Cells” In this review, researchers explored how various cell types and molecular mechanisms contribute to wound-induced hair follicle neogenesis, highlighting its potential as a therapeutic approach for regenerating hair follicles and minimizing scar formation after injury.
March 2020 in “Journal of lasers in medical sciences” This study found that HERC6 and its neighboring genes play a significant role in the cellular response of human skin to CO2 laser therapy, highlighting key biological processes related to gene expression changes post-treatment.
1 citations
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January 2022 in “Faculty reviews” This review discusses recent advances in understanding hair growth mechanisms and reviews current and emerging therapies, but it presents no new clinical results.
733 citations
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September 2009 in “Journal of Cell Science” This article reviews the complex process of wound repair, emphasizing recent microarray studies and proteomic analyses, but reports no new clinical results.
344 citations
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May 2018 in “EMBO journal” This review discusses the regulation of the MiT-TFE family transcription factors, particularly TFEB, through phosphorylation-mediated subcellular localization and reports no new clinical results.
91 citations
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December 2006 in “Proceedings of the National Academy of Sciences” In this study, researchers found that hair follicle orientation in Fz6 −/− mice is disrupted and that hair may reorient itself over time through a self-organized process.
76 citations
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January 2022 in “Journal of Tissue Engineering” This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.
39 citations
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May 2015 in “Advanced drug delivery reviews” This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.
31 citations
,
July 2017 in “Stem cell investigation” This article discusses the use of platelet-rich plasma as a supportive treatment for hair loss, emphasizing its potential to enhance hair follicle health and patient satisfaction, but reports no new clinical results.
12 citations
,
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.
6 citations
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October 2009 in “Veterinary Dermatology” This study identified various cell types in the canine claw, showing complex mechanisms of cellular differentiation similar to mammalian hair and human nails.
2 citations
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May 2023 in “Plants” In this study, Allium hookeri extract increased viability and size of dermal papilla cell spheroids and reduced oxidative stress effects, potentially promoting hair growth by regulating specific protein signaling pathways in human cells.