October 2021 in “Journal of Investigative Dermatology” Skin cell strength decreases significantly as we age.
PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.
122 citations,
April 1995 in “Journal of Cutaneous Pathology” The document describes how to tell different types of non-scarring hair loss apart by looking at hair and scalp tissue under a microscope.
75 citations,
February 2017 in “Aging” SkQ1 antioxidant improved health and lifespan in mice.
54 citations,
January 2023 in “Signal Transduction and Targeted Therapy” New therapies are being developed that target integrin pathways to treat various diseases.
51 citations,
January 2004 in “Skin Pharmacology and Physiology” The document explains hair growth and shedding, factors affecting it, and methods to evaluate hair loss, emphasizing the importance of skin biopsy for diagnosis.
30 citations,
September 2016 in “Aging Cell” Low selenium levels can extend lifespan but worsen health issues.
7 citations,
June 2021 in “Cell Proliferation” Low oxygen levels improve the function of hair and skin cells when they are in direct contact.
November 2024 in “BMC Research Notes” SIRT3 and SIRT7 genes may play a role in hair loss.
July 2024 in “Clinical Cosmetic and Investigational Dermatology” Non-drug therapies show promise for hair regrowth but need more research.
March 2024 in “Healthcare” Stem cell treatment improved life quality and sexual function in women with hair loss.
Different stem cells are key for hair growth and health, and understanding their regulation could help treat hair loss.
7 citations,
March 2023 in “Antioxidants” Rosemary may help treat various skin conditions due to its antioxidant and anti-inflammatory properties.
1 citations,
March 2023 in “Science Translational Medicine” Blocking a certain signal in the gp130 receptor can improve tissue healing and lessen osteoarthritis symptoms.
October 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Genetic manipulations that extend lifespan in mice may not work as effectively in humans.
February 2024 in “Molecules/Molecules online/Molecules annual” NMN could potentially treat hair loss by reducing oxidative stress and improving cell health.
41 citations,
February 2021 in “Translational research” Non-coding RNAs could help detect and treat radiation damage.
450 citations,
January 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair color is determined by melanin produced and transferred in hair follicles.
June 2024 in “Regenerative Therapy” Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.
August 2022 in “Regenerative Medicine” Adipose-derived stem cells show promise for cosmetic treatments but need more research.
489 citations,
November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
51 citations,
March 2018 in “Journal of Investigative Dermatology” Current murine models need improvement for better human wound healing research translation.
23 citations,
October 2021 in “Cell Stem Cell” Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
13 citations,
May 2021 in “FASEB bioAdvances” Plant-based products can improve hair and skin health without harmful side effects.
9 citations,
March 2023 in “Biomimetics” New materials that better mimic natural skin structure could improve healing, especially for chronic wounds.
5 citations,
November 2021 in “Frontiers in Cell and Developmental Biology” Caffeine can damage hearing cells and affect hearing recovery after ear trauma.
5 citations,
May 2021 in “EMBO journal” Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
5 citations,
May 2018 in “Therapeutic advances in drug safety” Androgen use may increase the risk of stroke, but more research is needed.
3 citations,
May 2022 in “Experimental Dermatology” Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.
2 citations,
June 2016 in “International journal of experimental pathology” Human skin has less GDNF and its receptor with age.