82 citations,
May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.
41 citations,
April 2016 in “Journal of experimental botany” RACB in barley is crucial for cell polarity and nucleus positioning, aiding fungal infection.
54 citations,
October 2002 in “Journal of controlled release” Medium lipophilic substances penetrate skin best, and adding ethanol can increase delivery to hair follicles.
1 citations,
January 2024 in “Theranostics” Exosomes show promise for future tissue regeneration.
1 citations,
May 2001 in “Pharmacology & Toxicology” Cyproterone acetate may cause liver cancer at high doses, but is considered safe at recommended doses for approved uses.
August 2023 in “Journal of Cosmetic Dermatology” Exosomes from hair papilla cells and the Chinese medicine Liao Tuo Fang can potentially promote hair growth and could be used to develop hair growth drugs.
1 citations,
April 2024 in “Skin research and technology” Topical rosuvastatin and melatonin creams significantly reduce psoriasis severity and are safe.
May 2024 in “Skin research and technology” Certain metabolites can either protect against or increase the risk of hair loss.
10 citations,
October 2001 in “PubMed” The conclusion is that substances can penetrate hair fibers through multiple pathways, including both the cell membrane complex and the non-keratinous parts.
June 2010 in “Melanoma research” LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.
6 citations,
December 2018 in “International Journal of Cosmetic Science” CARB is a strong barrier in human hair that prevents dye penetration.
6 citations,
September 2019 in “Skin pharmacology and physiology” RCS-01 therapy is safe and may improve skin structure by affecting gene expression.
11 citations,
January 2000 in “Journal of cosmetic science” Hydrolyzed wheat proteins penetrate all hair types effectively.
1 citations,
October 2022 in “Iet Nanobiotechnology” The dutasteride nanoemulsion could improve hair loss treatment by enhancing drug penetration and retention in hair follicles.
2 citations,
September 2016 in “Journal of Dermatological Science” Squarticles, tiny particles made from sebum-derived lipids, can effectively deliver minoxidil, a hair growth drug, directly to hair follicles and skin cells, with less skin penetration and more tolerability.
September 2024 in “Colloids and Surfaces B Biointerfaces” Cedrol nanoemulsions effectively treat hair loss by promoting hair growth and reducing DHT levels safely.
11 citations,
April 2015 in “EBioMedicine” JAK inhibitors may help treat Alopecia Areata but need careful monitoring due to side effects.
3 citations,
April 2015 in “International research journal of pharmacy” Gentamicin penetrates pig skin better through open hair follicles than blocked ones.
January 2021 in “Figshare” Tiny lipid particles carrying 17-α-estradiol gather in hair follicles, which may help target alopecia treatment.
14 citations,
February 2021 in “International Journal of Pharmaceutics” Deer antler velvet serum helps hair grow and is safe for skin.
July 2023 in “Journal of Cosmetic Dermatology” Ethosomes could improve how well skin treatments work, but more research is needed on their safety and stability.
4 citations,
May 2022 in “Journal of Drug Delivery Science and Technology” Nanoliposomes effectively deliver hair-growth peptides into hair follicles.
1 citations,
January 2023 in “Journal of pharmaceutical and biological sciences” Ethosomes are a promising way to deliver drugs through the skin.
43 citations,
August 2016 in “International Journal of Nanomedicine” Eupafolin nanoparticles help protect skin cells from damage caused by air pollution.
9 citations,
February 2022 in “European Journal of Pharmaceutics and Biopharmaceutics” A new treatment for hair loss uses tiny lipid carriers to deliver a mix of minoxidil and latanoprost directly to hair follicles, promoting hair growth and being well tolerated by the skin.
January 2021 in “Social Science Research Network” The new treatment using tiny lipid carriers to deliver minoxidil and latanoprost directly to hair follicles shows promise for alopecia.
5 citations,
May 2020 in “Pharmaceutical Research” Heat and chemicals improve finasteride delivery to scalp and hair follicles, potentially enhancing treatment for hair loss.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” QMSI is a valuable method for studying drug penetration in skin tissues.
129 citations,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
7 citations,
July 2019 in “International Journal of Molecular Sciences” PGA-4HGF may help treat hair loss by activating hair growth pathways and extending the hair growth phase.