August 2024 in “Stem Cell Research & Therapy” This review discusses current and emerging therapies for androgenetic alopecia, emphasizing regenerative treatments and nanotechnology advancements, but it reports no new clinical results.
July 2025 in “World Journal of Stem Cells” This review highlights that exosome-based therapies show promise for hair regeneration by modulating signaling pathways and enhancing hair follicle regeneration; however, further clinical research is needed due to variability in methods and limited clinical studies.
June 2022 in “Journal of Dermatology Research” This study found that 448-kHz Capacitive-Resistive Electrothermal Therapy led to a significant increase in hair density in women with Female Pattern Hair Loss, likely due to stimulated proliferation of dermal papilla cells.
28 citations
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August 2015 in “Journal of functional biomaterials” This review examines cell-based therapies for limbal stem cell deficiency, highlighting epidermal and hair follicle-derived stem cells as promising candidates for future clinical trials, but reports no new clinical findings.
May 2026 in “Medical Sciences” This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.
November 2025 in “Journal of Craniofacial Surgery Open” This study highlights exosome-based therapies as promising treatments for androgenetic alopecia, detailing protocol development, quality control measures, and clinical application examples, with mesenchymal stem cell-derived exosomes improving hair density in a case study without adverse effects.
This review reports that hair follicles are dynamic neuro-immuno-endocrine organs with intrinsic signaling pathways, which play a crucial role in hair disorders like alopecia. It highlights emerging regenerative approaches targeting these pathways for hair restoration.
69 citations
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February 2021 in “PLoS Computational Biology” This study found that securinine and ajmaline significantly inhibited hepatocellular carcinoma cell viability and induced apoptosis, with securinine showing lower toxicity to normal liver cells.
9 citations
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October 2024 in “Heliyon” In this review, the authors discuss the promising role of exosomes from various cell sources as potential cell-free therapies for diabetic foot ulcers, highlighting their therapeutic benefits in wound healing and the challenges faced in their clinical application.
7 citations
,
January 2020 in “PubMed” In this review, researchers highlight preclinical and clinical studies on stem cell-based therapies for hair loss, noting promising early findings but indicating that further robust clinical research is necessary to better understand their effectiveness, safety, and mechanisms.
July 2024 in “British journal of surgery” This review reports that regenerative medicine, such as autologous stem cell micrografting and Rigenera®, may significantly improve hair density in individuals with androgenetic alopecia, highlighting its potential as a future therapeutic option that addresses current treatment limitations.
November 2025 in “Frontiers in Oncology” This study found that Si extract, cryptomeridiol, and SiAgNPs have the ability to induce cell death and prevent cell growth in HepG2 liver cancer cells, suggesting cryptomeridiol's potential as a phytochemical component in developing new therapies for hepatocellular carcinoma using nanotechnology in vitro.
15 citations
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June 2023 in “Molecules” This study focused on developing agarose/fucoidan hydrogels for the encapsulation of pancreatic cells, reporting that these materials supported cell viability and self-organization into pseudo-islets over 7 days, highlighting potential for diabetes treatment applications.
April 2026 in “Cytotherapy” This study identifies macrophage-mediated immune signaling as a crucial factor in activating hair follicle stem cells and promoting hair regeneration, offering a new model for testing regenerative therapies for alopecia.
January 2024 in “Wiadomości Lekarskie” This study outlines new strategies for overcoming "cold" tumors, which are typically unresponsive to cancer immunotherapy, with approaches like dendritic cell-based treatments and local immune microenvironment modification, bolstered by both preclinical and clinical trial data.
157 citations
,
May 2021 in “Endocrine Reviews” This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.
149 citations
,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” This article provides contact information for Bruce A. Morgan and features no new research findings.
146 citations
,
July 2018 in “Regenerative Medicine” This review updates the understanding of fibroblast heterogeneity in wound healing, discussing advancements in fibroblast roles and potential therapies, but it reports no new clinical results.
143 citations
,
September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
91 citations
,
March 2011 in “Stem Cell Reviews and Reports” This article describes protocols for isolating and expanding human epidermal neural crest stem cells and discusses their potential for cell-based therapies in regenerative medicine, but reports no new clinical results.
35 citations
,
May 2012 in “Expert Opinion on Pharmacotherapy” This review summarizes current and emerging treatments for common hair loss conditions, highlighting good evidence for androgenetic alopecia but noting the lack of long-term data for alopecia areata and cicatricial alopecias.
32 citations
,
November 2012 in “Aesthetic Surgery Journal” This article reviews advancements in hair restoration, highlighting improvements in surgical techniques and patient satisfaction, but reports no new clinical results.
31 citations
,
May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses the physiology of hair follicles, their disorders, and the principles behind developing treatments, reporting no new results.
27 citations
,
September 2018 in “Nanomedicine: Nanotechnology, Biology and Medicine” This review discusses recent advances in hair regeneration therapies, highlighting the potential of nanotechnology and pluripotent stem cells, and reports no new results, emphasizing the need for further research.
25 citations
,
April 2021 in “npj Regenerative Medicine” This review highlights the potential role of mathematical and computational approaches in enhancing and accelerating the clinical translation of regenerative medicine products but reports no new clinical findings.
23 citations
,
June 2015 in “Experimental Dermatology” In this study, Mills et al. reported that inoculating human pericytes into murine wounds delayed dermal repair, revealing a need for better understanding of pericyte activity during skin injury repair.
12 citations
,
June 2018 in “Journal of Cosmetic Dermatology” This review outlines recent research on platelet-rich plasma, alone or combined with other therapies, for managing hair loss disorders, and discusses future prospects without reporting new clinical findings.
11 citations
,
September 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)” Various treatments exist for hair loss, but more research is needed for better options.
11 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This review discusses the history and challenges of hair follicle regeneration using follicular fragments and dissociated cells, without presenting new clinical results.
3 citations
,
March 2023 in “Life” This review discusses recent findings on wound healing with a focus on adipose tissue biology and obesity, but presents no new clinical results.