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The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Improving skin barrier and using antifungal treatments can help manage dandruff.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Skin problems are very common in people with end-stage kidney disease.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Spironolactone improved blood vessel function and cholesterol levels in non-obese women with PCOS.

Eclipta alba has many health benefits and contains compounds with potential for drug development.

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

Hormonal treatments are effective for severe or persistent acne and should be used with other acne therapies, considering potential side effects.

Male hormones, or androgens, affect women's health in areas like mood and bone density, and hormone replacement therapy using antiandrogenic progestogens can improve mood disorders and alertness in menopausal women.

New drug delivery methods can make natural compounds more effective and stable.

Intravaginal testosterone cream improves sexual satisfaction and reduces vaginal discomfort in postmenopausal women on breast cancer treatment without affecting hormone levels.

NSAIDs may not affect soft tissue healing but should be used carefully for bone fractures and more research is needed to understand sex differences in response.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Hedychium spicatum has medicinal properties but needs more research for scientific validation and use.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Chemotherapy can cause brain inflammation and damage, and understanding this process could help manage side effects.