20 citations
,
August 2020 in “Stem Cell Research & Therapy” This study found that miR-150 enhances the resolution ability of endothelial progenitor cells in venous thrombosis by promoting cell differentiation and proliferation through specific gene regulation pathways.
19 citations
,
November 2023 in “npj Regenerative Medicine” This study found that synthetic melanin particles applied topically in mouse injury models improved wound healing, showing potential as a therapy for accelerated healing, including in human skin explants.
19 citations
,
January 2017 in “Stem Cells International” This review discusses the potential of adipose-derived stem cells for treating vitiligo, hair loss, and chronic wound healing, but reports no new clinical results and suggests the need for further investigation.
17 citations
,
May 2021 in “Journal of Cell Science” In this study, the researchers discovered that specific polyamine depletion enhances stemness in hair follicle stem cells through a mechanism independent of mRNA translation.
15 citations
,
January 2017 in “Polymers” This review discusses how engineering cell surfaces with polyelectrolytes can address challenges in cell therapy and related biomedical fields and reports no new research findings.
15 citations
,
September 2014 in “PloS one” This study found that HIF1 and mTORC1 signalling were active in both basal cell carcinoma and trichoepithelioma, but the pathways do not reliably differentiate between the two.
14 citations
,
January 2018 in “Advances in Clinical Chemistry” This review discusses the evaluation of hyperandrogenemia in women and hypogonadism in men across different life stages and presents biomarkers used for diagnosing male hypogonadism, reporting no new clinical results.
14 citations
,
June 2017 in “Immunity” This study found that skin-resident Treg cells regulate hair follicle stem cell proliferation and differentiation through the Jag1-Notch signaling pathway, influencing hair regeneration.
14 citations
,
June 2015 in “Toxicology and Industrial Health” This study found that low doses of bisphenol A may increase proliferation of the ventral prostate in adult rats by altering the estrogen to androgen ratio and gene expression.
13 citations
,
January 2016 in “Journal of cosmetology & trichology” This review discusses the emerging pathophysiological factors and potential new therapies for androgenetic alopecia beyond traditional treatments, but reports no new results.
13 citations
,
January 2010 in “Advances in Biochemical Engineering / Biotechnology” This review covers various aspects of hair biology, pigmentation, and development, focusing on genetic and biochemical modulation of hair follicle components but reports no new findings.
13 citations
,
August 1999 in “Journal of Investigative Dermatology” This study found that bikunin is expressed in human keratinocytes and may play a role in regulating keratinocyte function during mitosis or inflammation.
12 citations
,
May 2024 in “International Journal of Nanomedicine” This review discusses the potential of stem cell-derived extracellular vesicles for improving diabetic wound healing and highlights their mechanisms, limitations, and challenges, but provides no new clinical findings.
9 citations
,
March 2022 in “Journal of radiation research” This study identified specific profiles and courses of adverse events associated with boron neutron capture therapy for head and neck cancer, suggesting differences based on the beam incidence site.
9 citations
,
March 2011 in “Current Pharmaceutical Biotechnology” This review discusses current stem cell technologies, their potential therapeutic uses, and imaging techniques for tracking transplanted cells, without reporting new experimental results.
7 citations
,
March 2025 in “Free Radical Biology and Medicine” This study discusses how redox imbalance, specifically through reduced Insulin-like Growth Factor-1 mediated by the transcription factor JunB and sphingolipid metabolism changes, contributes to skin aging by depleting stem cell pools and altering the extracellular matrix, ultimately impacting skin integrity and function.
7 citations
,
October 2020 in “Journal of Clinical Medicine” In this study, researchers found that overweight and obese women with polycystic ovary syndrome showed adverse changes in glucose metabolism over time, highlighting the importance of early intervention to prevent cardiometabolic diseases.
7 citations
,
October 2019 in “Clinical, Cosmetic and Investigational Dermatology” This study found that specific polymorphisms in the VDR gene, Taq1, and Cdx1, were significantly associated with increased risk of chronic telogen effluvium in women.
7 citations
,
August 2017 in “Journal of dermatological science” This study found that sorafenib increased mast cell number and degranulation in skin, suggesting PI3K signaling and SCF production may underlie its adverse cutaneous reactions.
7 citations
,
March 2017 in “Medical Hypotheses” This study suggests that dysfunctions and altered expression of aquaporins may play a role in PCOS-related disorders, potentially impacting folliculogenesis and integrating with the insulin-dependent hypothesis of PCOS pathogenesis.
7 citations
,
May 2014 in “Clinical practice” This article reviews drug-induced hair and nail disorders and discusses their clinical recognition, underlying mechanisms, and potential treatment strategies, without presenting new research findings.
7 citations
,
April 2013 in “Clinical and Experimental Dermatology” This study found that tianeptine may suppress the transition to catagen, promoting hair growth in a stress-induced alopecia areata mouse model.
6 citations
,
June 2019 in “Biotechnology Letters” Gene therapy shows promise for improving wound healing, but more research is needed for human use.
5 citations
,
June 2024 in “Free Radical Biology and Medicine” This review highlights that current in vitro models often fail to replicate the physiological oxygen levels experienced by different skin cell types, which could affect redox states and functions, potentially accelerating skin aging.
4 citations
,
June 2022 in “Frontiers in Cell and Developmental Biology” Plant extracts might help control stem cell growth for medical use.
3 citations
,
December 2024 in “Stem Cell Reports” In this study, researchers observed that low levels of fucose-binding lectin staining characterize limbal epithelial progenitor cells, which maintain a high proliferative capacity and may be enhanced by inhibiting fucosylation, offering insights for regenerative therapy of the limbal stem cell niche.
3 citations
,
January 2021 in “touchREVIEWS in Endocrinology” This case report describes how a 68-year-old woman's hyperandrogenic symptoms improved and testosterone levels normalized after the surgical removal of an occult Leydig cell tumour.
3 citations
,
October 2018 in “Archives of Dermatological Research” This study suggests that the InlB321/15 protein may accelerate wound healing by increasing cell proliferation and reducing wound closure time in both cell culture and mouse models.
2 citations
,
March 2021 in “Molecular Immunology” This review discusses the role of dermal macrophages in stress-induced hair regeneration and reports no new clinical findings, highlighting the need for further research into macrophage dynamics for potential hair loss therapies.
2 citations
,
March 2015 in “Expert opinion on orphan drugs” This review discusses recent advances in the treatment of alopecia areata, highlighting new potential therapies like JAK inhibitors and PRP, and reports no new clinical results.