April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that low-dose blue light (453nm) may positively affect hair growth by interacting with the receptors CRY1 and OPN3 in hair follicle cells.
106 citations
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July 2013 in “Advances in wound care” This review discusses the potential of ultraviolet (UV) radiation technologies in wound care, highlighting their antimicrobial properties and risks of DNA damage, but reports no new clinical findings.
March 2024 in “International journal of molecular sciences” In a mouse model study, transcutaneous auricular vagus nerve stimulation (taVNS) significantly reduced depigmentation in vitiligo, potentially through mechanisms that regulate oxidative stress and inflammation, indicating taVNS's promise as a therapeutic approach for this skin disorder.
May 2023 in “The Journal of Immunology” In this study of C3H/HeJ mice, researchers observed that alopecia areata is associated with the expansion of exhausted-memory CD8 T cells in multiple organs, with autoreactive activation not fully explained by known mechanisms, shedding light on the immunological dynamics underlying the condition.
15 citations
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January 2015 in “Pharmaceutical Biology” In a study on nude mice, topical application of Chrysanthemum zawadskii extracts stimulated hair growth and increased hair follicle numbers, suggesting potential for alopecia therapy.
April 2021 in “Journal of Investigative Dermatology” This trial found that intradermal injections of the Hair Stimulating Complex were well-tolerated and effectively stimulated hair growth and prevented hair loss in male pattern baldness participants over 18 weeks.
September 2017 in “Journal of Investigative Dermatology” In this study, low-dose 453 nm blue light appeared to enhance hair growth by interacting with specific photoreceptors in the outer root sheath cells.
115 citations
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August 2008 in “The Journal of Clinical Endocrinology & Metabolism” In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.
69 citations
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January 1995 in “PubMed” This study suggests that the structure and function of mouse melanocytes in the epidermis and hair bulb are influenced by genetic factors and local tissue environment, including hormones and growth factors.
13 citations
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December 1987 in “British Journal of Dermatology” This study suggests that increased T cell blastogenesis may predict a positive response to topical 5% minoxidil treatment in patients with severe alopecia areata.
January 2014 in “프로그램북(구 초록집)” This study suggests that certain electrical settings may enhance hair growth by stimulating dermal papilla cell proliferation and increasing gene expression related to hair growth in vitro and in rabbit skin.
4 citations
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January 2004 This study found that while some extracts from DanGuiBoHyulTangGami-Bang showed potential in inhibiting 5-reductase type Ⅱ and had antioxidant activity, they were not effective in extending the hair growth period.
April 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This study utilized computational approaches to screen natural compounds targeting a non-androgen pathway involving PIEZO1 and MLCK for treating androgenetic alopecia, identifying several potential candidates for further validation but making no clinical claims.
December 2022 in “Scientific Reports” This study found that caffeic acid amide derivative, compound 4, effectively inhibited steroid 5α-reductase type 1 in vitro, suggesting potential for development as a treatment for androgenic alopecia.
40 citations
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September 2024 in “Heliyon” This review discusses the role of bioceramics, highlighting their bactericidal activity, lack of side effects, and ability to release metallic ions for hard and soft tissue repair. The authors suggest that integrating bioceramics with other biomaterials could offer a cost-effective, efficient alternative for wound healing.
14 citations
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April 1987 in “PubMed” In an open trial, 2.8% minoxidil solution applied topically stimulated new hair growth in 45% of male patients with male pattern alopecia, though patient self-assessments were more favorable than objective evaluations.
November 2025 in “Medical alphabet” This study highlights that physiotherapeutic methods like low-intensity laser therapy, radiofrequency, and electrical stimulation show promising effectiveness in stimulating hair growth and treating telogen effluvium by enhancing cell activity, ATP synthesis, and transdermal drug delivery.
277 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
101 citations
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October 2016 in “Nanomedicine: Nanotechnology, Biology and Medicine” This review reports on the dual aspect of fullerene in skincare, highlighting its beneficial antioxidant properties as well as potential toxicity and skin cell reactions, while identifying areas for future research.
39 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article discusses the role of growth hormone, insulin, and IGF-1 in acne development and highlights how diet and syndromic evidence support their involvement, but presents no new clinical findings.
28 citations
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March 2019 in “Journal of Dermatological Science” This review discusses methods for evaluating hair growth-promoting effects of candidate substances for androgenetic alopecia, focusing on cell assays, organ cultures, and animal models, and reports no new results.
25 citations
,
April 1949 in “The journal of experimental zoology” This research studied the effect of local testosterone propionate applications on rabbit epidermal mitotic activity but reports no new results.
The study found that adipose-derived mesenchymal stem cells obtained via laser-assisted liposuction with selective photo-stimulation are comparable in differentiation potential and tumorigenic risk to those from conventional liposuction for cell therapy applications.
April 2016 in “Journal of Investigative Dermatology” The researchers reported that SOX4 expression is significantly upregulated in melanoma and its knockdown in cell lines resulted in reduced tumor progression, suggesting potential for targeted therapies.
14 citations
,
January 2020 in “Frontiers in Endocrinology” This study reports that in ovarian cell development, FSH-induced OCT4 expression is regulated through the GSK3β/β-catenin pathway mediated by the PI3K/Akt pathway.
April 2023 in “Research Square (Research Square)” This study found that melatonin-mediated lncRNA018392 accelerated cell proliferation and inhibited apoptosis in cashmere goat skin fibroblasts by upregulating the expression of the nearby gene CSF1R.
1 citations
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January 2004 This review discusses epithelial-mesenchymal interactions in hair follicle development and their regulation by molecular signals, but reports no new results; the authors emphasize the need for further research to apply these findings clinically.
October 2023 in “Biomaterials” This review highlights the potential of nanotechnology for hair follicle regeneration, focusing on strategies such as hair cycle modulation, progenitor cell stimulation, and wound-induced hair neogenesis, while also discussing regulatory challenges that may affect the development of these innovative approaches.
98 citations
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July 2014 in “Trends in Molecular Medicine” This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.
8 citations
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March 2013 in “Cell Transplantation” In this study, intradermal injection of GCSF-mobilized peripheral blood stem cells from young pigs rejuvenated skin in aged pigs by increasing collagen, elastin, and cell renewal rates.