56 citations
,
December 2011 in “The Plant Journal” AGD1 is important for root hair development in Arabidopsis, working with phosphoinositide signaling and the actin cytoskeleton.
55 citations
,
August 2024 in “Heliyon” This review article highlights recent progress and challenges in stem cell transplantation for regenerative medicine, emphasizing its potential in tissue repair for conditions like bone and cartilage injuries, neurological disorders, and blood diseases, while stressing the importance of overcoming current obstacles for future advancements.
46 citations
,
June 2015 in “American Journal Of Pathology” This review highlights how diabetes affects stem and progenitor cells through altered signaling and homeostasis, impacting tissue function and complicating diabetic therapy efforts; new clinical results are not presented.
46 citations
,
December 2006 in “Anais Brasileiros de Dermatologia” This study identified acne, superficial mycoses, pigmentation disorders, and actinic keratosis as the most common dermatologic diagnoses in Brazil, emphasizing the importance of skin cancer and leprosy in public health.
44 citations
,
March 2004 in “Journal of Investigative Dermatology” This study observed that in vitro treatment of male frontotemporal scalp hair follicles with 17-β-estradiol stimulated hair shaft generation and hair matrix keratinocyte proliferation, suggesting potential anagen-prolonging effects.
42 citations
,
February 2016 in “Science” The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.
40 citations
,
August 2022 in “Frontiers in immunology” This review discusses the potential of JAK inhibitors as a promising treatment strategy for alopecia areata, highlighting their mechanism and recent FDA approval based on clinical trial efficacy.
37 citations
,
February 2019 in “Experimental Dermatology” This study explored the regenerative abilities of the African spiny mouse's skin, revealing more robust wound-induced hair follicle neogenesis compared to laboratory mice and highlighting unique features of its hair and wound response.
34 citations
,
February 2015 in “Frontiers in Cellular Neuroscience” This study identified new genes and compounds affecting hair cell survival during ototoxin exposure using the zebrafish model, potentially aiding in understanding and preventing hearing loss and balance disorders in humans.
30 citations
,
November 2018 in “EMBO Reports” This study found that the Ovol2-Zeb1 regulatory circuit is crucial for controlling directional migration and proliferation in epithelial cells, facilitating skin regeneration and repair in mice.
29 citations
,
September 2014 in “American Journal of Dermatopathology” This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.
26 citations
,
January 2019 in “Expert Opinion on Investigational Drugs” This review explored the new and emerging treatments for androgenetic alopecia and alopecia areata, finding that JAK inhibitors show promise for alopecia areata, while advancements in stem-cell research may eventually lead to new and improved treatments for androgenetic alopecia.
25 citations
,
October 2018 in “Journal of The American Academy of Dermatology” This study concluded that erosive pustular dermatosis of the scalp may be a type of spongiotic, pustular superficial folliculitis, sharing similarities with other neutrophilic dermatoses.
25 citations
,
November 2014 in “British Journal of Dermatology” This study found various ABC transporters are transcribed in human hair follicles, suggesting their possible role in HF biology and potential for new therapeutic interventions.
25 citations
,
June 2013 in “Obesity Reviews” This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.
19 citations
,
January 2013 in “Frontiers in Neuroanatomy” This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.
18 citations
,
January 2019 in “Experimental Dermatology” This study suggests that damaged anagen hair follicles have the capability to repair themselves and resume growth by mobilizing extra-bulge epithelial cells, particularly after injuries like chemotherapy and radiotherapy.
15 citations
,
September 2019 in “Science as Culture” This study discusses the rise of commercial direct-to-consumer stem cell therapies, highlighting how they are marketed as biomedical 'lifestyle' products that blend science, medicine, and consumer culture, despite ongoing safety and efficacy concerns.
14 citations
,
February 2020 in “Scientific reports” This study found that telocytes in human scalp tissue were located around hair follicles and glands and may be involved in skin regeneration and homeostasis.
13 citations
,
March 2018 in “Journal of Sociology” This article argues that the promissory discourse in the anti-ageing treatments market exploits societal anxieties about ageing, but its long-term sustainability is questionable as many promises remain undeliverable.
13 citations
,
January 2016 in “Journal of cosmetology & trichology” This review discusses the emerging pathophysiological factors and potential new therapies for androgenetic alopecia beyond traditional treatments, but reports no new results.
12 citations
,
September 2014 in “Journal of Food Science and Nutrition” This study suggests that Platycarya strobilacea extract promotes hair growth in mice by enhancing stem cell factor expression, reducing mast cell numbers, and increasing cytokines associated with hair growth.
12 citations
,
May 2001 in “British journal of dermatology/British journal of dermatology, Supplement” A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.
9 citations
,
July 2020 in “Experimental Dermatology” This review emphasizes the potential of repurposing topical L-thyroxine for skin ulcers and telogen effluvium and highlights the need for further exploration of its use in dermatology.
9 citations
,
August 2014 in “The Journal of Dermatology” This study found that clinically non-affected perilesional scalp in Japanese alopecia patients often showed microscopic abnormalities, which may help in assessing the spread of disease activities.
8 citations
,
June 2011 in “Nature Biotechnology” Stem cell treatments can potentially treat baldness, with one trial showing hair growth after injecting a hair-stimulating complex, and no safety issues were reported.
8 citations
,
January 2007 in “International journal of experimental pathology” This study observed that hairless HRS/J mice were resistant to Bacillus anthracis infection at the skin's surface, suggesting resistance may be due to increased dermal neutrophils rather than non-functional hair follicles.
7 citations
,
May 2022 in “Frontiers in Cell and Developmental Biology” This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.
6 citations
,
January 2010 in “Actas Dermo-Sifiliográficas” This review covers the current procedure for follicular unit hair transplantation, noting that recent advancements have made the results natural and undetectable, but it presents no new experimental findings.
5 citations
,
June 2022 in “Biophysical Journal” This study used a probabilistic Boolean network model to explore hair follicle cell fate regulation and predicted that varying TGF-β levels, in coordination with BMP and TNF, can influence either apoptosis or cell proliferation during different follicle growth stages.