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    Glossary Cell Reprogramming

    process of converting specialized cells into stem cell-like states

    Cell Reprogramming, also known as Cellular Reprogramming, is a process where specialized cells, such as skin cells, are converted back into a more primitive, stem cell-like state. This is typically achieved by introducing specific genes or proteins that reset the cell's identity, allowing it to potentially develop into different types of cells. This technique holds significant promise for regenerative medicine, including treatments for conditions like alopecia, where new hair follicles could be generated from reprogrammed cells.

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    1. Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice 2022 · 14 citations
    2. Regulation of somatic cell reprogramming through inducible mir-302 expression Nucleic acids research · 2010 · 308 citations
    3. Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule Biochemical Pharmacology · 2025
    4. Hypoxia in Cell Reprogramming and the Epigenetic Regulations Frontiers in Cell and Developmental Biology · 2021 · 36 citations
    5. Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances · 2022 · 16 citations
    6. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    7. Small molecules facilitate single factor-mediated sweat gland cell reprogramming Military Medical Research · 2022 · 9 citations
    8. Stem cell dynamics, migration and plasticity during wound healing Nature Cell Biology · 2018 · 211 citations
    9. Cell fate decisions: emerging roles for metabolic signals and cell morphology EMBO Reports · 2017 · 100 citations
    10. Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells Journal of Investigative Dermatology · 2012 · 26 citations
    11. Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells Biochemical Society Transactions · 2014 · 4 citations
    12. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature · 2010 · 116 citations
    13. Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate Genes · 2019 · 28 citations
    14. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations
    15. Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model · 2017 · 3 citations
    16. Pluripotent Stem Cell Technology: A Promising Remedy for Hypopigmentation Disorders Journal of Stem Cell Research & Therapeutics · 2017 · 1 citations
    17. Shushing down the epigenetic landscape towards stem cell differentiation Development · 2010 · 1 citations
    18. Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis Journal of Inflammation Research · 2024
    19. Reprogramming of Aged Dermal Papilla Cells in Vitro: In Silico Insight into the Biomarkers of Hair Growth and Tissue Repair Preprints.org · 2025
    20. Small RNAs Loom Large During Reprogramming Cell stem cell · 2011 · 18 citations
    21. Faculty Opinions recommendation of Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    22. Synergistic antioxidant-antimicrobial-immunomodulatory self-healing “radical sponge” hydrogel for diabetic wound regeneration via microenvironment reprogramming mediated by coordinated MAPK suppression and PI3K-AKT activation Chemical Engineering Journal · 2026
    23. Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives Stem Cells International · 2019 · 17 citations
    24. Differential Expression of Proteins Associated with the Hair Follicle Cycle - Proteomics and Bioinformatics Analyses PLOS ONE · 2016 · 10 citations
    25. Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration Molecules and Cells · 2023
    26. Chitosan in Dermatology Clinical dermatology open access journal · 2018
    27. The extracellular matrix dictates regional competence for tumour initiation Nature · 2023 · 24 citations
    28. THBS4 promotes hair regeneration by inducing dermal mechanical niche adaptation Research Square · 2026
    29. p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials Cell Death Discovery · 2026
    30. Scar Inhibition in Wound Healing: Mechanisms, Design, and Recent Advances Exploration · 2026