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This article describes a method using the CUBIC protocol to clarify and visualize molecular and cellular interactions in mouse skin biopsies at single cell resolution, but does not provide new biological findings.

This study found that the mammalian Hr protein can interact with the p53 pathway by binding to a specific p53 response element, influencing the regulation of genes involved in cell cycle control.

This study observed that nestin-positive, K15-negative cells in hair follicles may play a crucial role in hair follicle regeneration in patients with alopecia areata.

Aged skin heals slower due to more inflammation and disrupted cell communication.

This study used a probabilistic Boolean network model to explore hair follicle cell fate regulation and predicted that varying TGF-β levels, in coordination with BMP and TNF, can influence either apoptosis or cell proliferation during different follicle growth stages.

This study indicates that individuals exposed to PPD mount varying immune responses, with either tolerance, subclinical inflammation, or allergy, suggesting no true non-responders to PPD.

This study identified high expression of the Sur2A subunit in cancerous cells in two animal models, highlighting a potential drug target in breast and renal cancers, with additional pharmacovigilance data linking KATP channel genes to varied cancer risks.

In their research, Yucel and colleagues found that CaV1.2 is expressed in hair follicle stem cells, facilitating anagen re-entry in a way not dependent on calcium flux.

This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.

In this study, researchers found that a PER3 gene SNP may be pathogenic for a new subtype of dyschromatosis universalis hereditaria, especially when combined with a SASH1 mutation.

This study found that hair follicle stem cells in the hairpoor mouse, a model for Marie-Unna hypotrichosis, lose their quiescent state, leading to a disordered hair cycle and contributing to alopecia.

In this study, researchers used quantitative fate mapping to investigate how the infundibulum, part of the epidermis, is maintained during adulthood, finding that progenitors maintain this tissue through stochastic cell fate choices, with cells at the bottom providing transient support during hair growth phases.

In this study, TrichotechTM, a phytocomplex derived from essential oils, enhanced fibroblast proliferation, increased FGF-7 and FGF-10 gene expression, and boosted collagen content in cultured human fibroblasts.

This review discusses the role of phospholipases in skin and hair health, suggesting that understanding their molecular control could inform new treatments for related conditions, but it presents no new clinical results.

This study found that aging mice with an epidermal deletion of DNA methyltransferase 1 had a reduced number of hair follicles, due to decreased stem cell activation probability.

This study found that upcycled postbiotic cell-free supernatants from Limosilactobacillus fermentum MG901 and MG4237 protected human dermal papilla cells from oxidative stress, enhancing wound-healing capacity and mitochondrial function, suggesting potential as a sustainable cosmetic ingredient for hair loss alleviation.

This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.

This study found that 808 nm laser photobiomodulation altered mitochondrial respiration and enhanced osteogenic protein expression in human dental pulp stem cells, with the effects being dose-specific and more pronounced at 15 J/cm².

In this study, researchers used a human skin organoid model to show that solar UV exposure damages hair follicles and skin, while exosomes from mesenchymal stem cells reduced inflammation and supported hair follicle regeneration.

In this study, exosome-loaded hydrogels derived from skin precursor cells significantly improved wound healing in diabetic rats by enhancing angiogenesis, reducing inflammation, and promoting tissue repair.

This review highlights the potential of plant-derived bioactive compounds as an alternative to current hair loss treatments by detailing the mechanisms and clinical evidence of eighteen traditional medicinal plants, and discusses future trends like nanotechnology and stem cell therapy in managing alopecia.

This report details a case study where a 40-year-old woman experienced allergic contact dermatitis and angioedema-like symptoms after using PPD-containing hair dye. Patch testing confirmed a positive reaction to PPD, highlighting the substance's potential to cause both T-cell and IgE-mediated hypersensitivity reactions.

This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.

This study highlights that physiotherapeutic methods like low-intensity laser therapy, radiofrequency, and electrical stimulation show promising effectiveness in stimulating hair growth and treating telogen effluvium by enhancing cell activity, ATP synthesis, and transdermal drug delivery.

This study found that exosomes from human umbilical cord mesenchymal stem cells significantly promoted hair follicle growth and enhanced the transition to the growth phase in a model of androgenetic alopecia, by enriching specific microRNAs that activate key pathways involved in hair regeneration.

This study reported that exosomes derived from human amniotic mesenchymal stem cells (hAMSC-exo) accelerated hair growth in androgenetic alopecia mice by enhancing signals between hair follicle cells and improving cellular environments, particularly protecting against dihydrotestosterone-induced damage via Wnt/β-catenin signaling.

This study found that mitochondrial fusion regulator Opa1 is crucial for maintaining melanocyte stem cells during the hair follicle cycle in mice, with Opa1 deficiency leading to impaired SCF-KIT signaling, reduced melanocyte populations, and early hair graying.

This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.

This review examines the molecular effects of photobiomodulation therapy, particularly its influence on gene and protein expression related to inflammation and cell functions, but reports no new clinical results.

This study found that extracts from Cirsium japonicum var. spinossimum seeds are rich in polyphenols and flavonoids, demonstrating significant anti-inflammatory and cell proliferation effects in specific cell models, suggesting potential as a source for anti-inflammatory and anticancer agents.