39 citations
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January 2013 in “Journal of Investigative Dermatology” This review explains how recent understanding of Wnt signaling regulation in hair follicles could potentially be used to enhance hair growth, but it reports no new empirical results.
November 2023 in “npj regenerative medicine” This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.
June 2025 in “Journal of Cosmetic Dermatology” This case study reports that reducing scalp massage following minoxidil application and using mesenchymal stem cell exosomes led to significant improvement in hair condition for a patient with trichorrhexis nodosa.
April 2018 in “Journal of Investigative Dermatology” Key signals for hair follicle formation were identified.
31 citations
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July 2017 in “Clinical Science” This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.
3 citations
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May 2022 in “Experimental Dermatology” This review discusses the role of hair follicle stem cell metabolism, ageing, and microenvironment in hair growth disorders and compiles recent research on using stem cell-based regenerative medicine for treating alopecia, without reporting new clinical results.
16 citations
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September 2022 in “Cold Spring Harbor Perspectives in Biology” This article explores how adult mammals can regenerate hair follicles after wounding and suggests that manipulating cell signals during healing might enhance this process, but provides no new experimental results.
8 citations
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January 2017 in “Methods in molecular biology” This article describes a protocol for using bioengineered techniques to regenerate functional hair follicles and their stem cell niches by manipulating epithelial and mesenchymal cells.
56 citations
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June 2015 in “Nature Protocols” This protocol describes using two-photon laser-scanning microscopy to study hair regeneration in live mice, offering detailed imaging capabilities for observing hair follicle stem cell behavior and manipulating cellular populations.
54 citations
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May 2015 in “Endocrinology” In this study, manipulation of the enzyme 5α-reductase type 2 in human hepatocytes altered lipogenesis, suggesting clinical implications for patients using 5α-reductase inhibitors by affecting glucocorticoid action on hepatic lipid metabolism.
34 citations
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January 2013 in “Frontiers in genetics” This review discusses how certain adult stem cells can produce factors that support the maintenance of other stem cell populations within shared niches, and it reports no new experimental results.
July 2026 in “Journal of Investigative Dermatology” Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.
December 2005 in “Current Prostate Reports” This review discusses the historical and current use of androgen manipulation for treating benign prostatic hyperplasia and reports no new clinical results.
July 2025 in “Journal of Investigative Dermatology” Wnt signaling helps regenerate hair follicles in wounds by reducing skin cell sensitivity to mechanical stress.
January 2022 in “Figshare” In this study, researchers found that dermal papilla cell exosomes can enhance hair follicle stem cell proliferation and reduce apoptosis through the Wnt3a/β-catenin signaling pathway, offering insights for potential hair problem treatments.
353 citations
,
May 2016 in “TrAC Trends in Analytical Chemistry” This review discusses recent advances in droplet microfluidics for chip-based technologies such as single-cell analysis, small-scale cell cultures, and high-throughput drug screening, and it reports no new results.
141 citations
,
August 2018 in “Nature Reviews Microbiology” This review discusses the molecular mechanisms by which oncogenic viruses contribute to cancer development through manipulation of host cellular functions and highlights the need for further research into virus-associated cancers, reporting no new results.
44 citations
,
January 2015 in “Development” This study reports that human epidermal neural crest stem cells from hair follicles can be quickly differentiated into highly pure human Schwann cells without genetic manipulation, suggesting their potential for therapeutic applications.
3 citations
,
January 2023 in “PloS one” In this study, hair-follicle-associated pluripotent stem cell implantation improved functional recovery and reduced inflammation in a mouse model of intracerebral hemorrhage.
April 2018 in “Journal of Investigative Dermatology” This study found that the protein p63 requires morphogenetic signals to regulate gene expression effectively during skin cell differentiation, highlighting its complex role in therapeutic reprogramming for conditions like epidermolysis bullosa.
1 citations
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October 2021 in “Indian Journal of Plastic Surgery” This paper reviews current data on regenerative medicine with stem cells for treating androgenic alopecia, highlighting recent advancements in simpler and minimally invasive techniques for stem cell isolation and application, though specific results are not detailed.
43 citations
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September 2009 in “Stem Cells” This study reported that GFP labeling driven by the K15 promoter enables visualization and selection of stem cells in adult human scalp hair follicles for further analysis and manipulation.
May 2024 in “Clinical Cosmetic and Investigational Dermatology” In this study, researchers reviewed the roles of autophagy and mitophagy in hair follicle cycles, exploring their potential links to hair loss and investigating how manipulating these pathways might offer new therapeutic strategies.
6 citations
,
January 2005 in “Biology of Blood and Marrow Transplantation” This article reviews various models of graft-versus-host disease, highlighting the complexity of its mechanisms and the challenges in interpreting histopathologic data; it reports no new results.
6 citations
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June 2021 in “The Journal of Experimental Medicine” This review discusses current technologies for analyzing signaling in hematopoietic stem and progenitor cells and reports no new results, highlighting the need for further research in this area.
79 citations
,
January 2015 in “Journal of Materials Chemistry B” This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.
3 citations
,
January 2017 in “Methods in molecular biology” This book reviews organogenesis in developmental biology and next-generation organ regenerative therapy but reports no new research findings.
123 citations
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January 2020 in “International Journal of Molecular Sciences” This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.
7 citations
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January 2017 in “Stem Cells International” This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.
This study found that in mice, the epidermal microenvironment reverses the oncogenic effects of GNAQQ209L in melanocytes, inhibiting their survival and proliferation through paracrine signals.