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Ionizing radiation causes irreversible skin damage, with single doses leading to acute injury and hair graying, and fractional doses causing more severe long-term tissue damage.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

Hair graying is caused by the loss of pigment cells due to poor maintenance of stem cells in the hair follicle.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

Stem cells help heal skin wounds by moving and changing roles, working with other cells, and needing more research on their activation and behavior.

Different types of skin cells play specific roles in development, healing, and cancer.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Certain mice without specific receptors or mast cells don't lose hair from stress.

Inactive hair follicle stem cells help prevent skin cancer.

The extracellular matrix is crucial for controlling skin stem cell behavior and health.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

miR-22, a type of microRNA, controls hair growth and its overproduction can cause hair loss, while its absence can speed up hair growth.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Ephrins slow down skin and hair follicle cell growth.

Mice can correct hair follicle orientation without certain genes, but proper overall alignment needs those genes.

ROOT HAIR SPECIFIC 10 (RHS10) reduces the length of root hairs in Arabidopsis plants.

Smad1 and Smad5 are essential for hair follicle development and stem cell sleepiness.