July 2023 in “Bioengineering & translational medicine” The study demonstrated that mesenchymal stem cell paracrine proteins (MSC-PP) derived from a 3D dynamic culture system, combined with PEG thermogel, significantly improved wound healing in third-degree burn models. The MSC-PP treatment enhanced the migration and proliferation of dermal fibroblasts and keratinocytes, reduced inflammation, and promoted re-epithelialization, skin appendage recovery, and angiogenesis. The PEG thermogel provided a stable release of MSC-PP and exhibited no cytotoxicity, making it an effective carrier for MSC-PP delivery. The MSC-PP + PEG group showed the most effective wound contraction, minimal scarring, and the highest presence of CD26+/Sca-1+ and Dlk-1+/Sca-1+ cells, which are crucial for inhibiting scar formation.
December 2022 in “Scientific Reports” Stem cells from whiskers can be transplanted to stimulate hair growth.
16 citations,
April 2021 in “Frontiers in Cell and Developmental Biology” New hair follicles could be created to treat hair loss.
3 citations,
November 2022 in “Experimental dermatology” Melatonin may inhibit melanoma growth and has potential as a cancer therapy aid, but its effects on human skin pigmentation need more research.
December 2023 in “Aggregate” Scientists are using clumps of special stem cells to improve organ repair.
December 2023 in “The journal of cell biology/The Journal of cell biology” The mTurq2-Col4a1 mouse model shows how the basement membrane develops in live mammals.
November 2022 in “CARDIOMETRY” A group has developed therapies that show promise for treating cancer and various other conditions.
4 citations,
December 2021 in “Journal of clinical laboratory analysis” A new mutation in the DCAF17 gene was found to cause Woodhouse-Sakati syndrome in a large family.
3 citations,
May 2013 in “International journal of molecular sciences” Epidermal stem cells show promise for treating orthopedic injuries and diseases.
August 2023 in “International Journal of Molecular Sciences” Human skin xenografting could improve our understanding of skin development, renewal, and healing.
2 citations,
January 2022 in “The Application of Clinical Genetics” This study reports a 1-year and 3-month-old Russian female with Meier-Gorlin syndrome (MGS) who exhibited severe growth retardation, respiratory issues, and distinct facial and skeletal abnormalities. Genetic analysis revealed two novel compound-heterozygous variants in the CDC6 gene, crucial for DNA replication. The patient showed typical MGS features such as microtia, absent patellae, and severe pre- and postnatal growth retardation. Exome sequencing confirmed the CDC6 gene mutations, adding to the limited reports of CDC6-related MGS and highlighting the genetic heterogeneity and clinical variability of the syndrome. The study underscores the importance of exome sequencing in diagnosing rare genetic disorders.
21 citations,
September 2015 in “International journal of gynaecology and obstetrics” Chemotherapy is crucial for treating gynecological cancers but requires careful management due to severe side effects.
19 citations,
March 2021 in “Experimental and Therapeutic Medicine” Isotretinoin can cause serious birth defects and needs careful use, especially in pregnant women.
99 citations,
January 2004 in “Progress in brain research” Neurotrophins are important for hair growth and could help treat hair loss.
65 citations,
February 2011 in “Molecular cancer therapeutics” CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.
18 citations,
July 2022 in “Frontiers in Immunology” Volatile organic compounds can cause inflammation and increase the risk of autoimmune diseases.
13 citations,
April 2019 in “International journal of molecular sciences” Acyzol could help treat conditions caused by zinc deficiency.
10 citations,
July 2022 in “Journal of Medicinal Chemistry” Adding a second method to PROTACs could improve cancer treatment.
April 2024 in “Skin appendage disorders” Environmental pollutants can damage hair health and cause hair loss.
March 2024 in “Antioxidants” Excessive blue light harms eye cells and disrupts sleep patterns.
January 2024 in “Journal of Ayurveda and integrative medicine” Millets may help reduce chemotherapy side effects like nausea, fatigue, and hair loss.
69 citations,
April 2010 in “Clinical ophthalmology” Bimatoprost is effective for growing longer, thicker, and darker eyelashes.
July 2024 in “Clinical Cosmetic and Investigational Dermatology” Exosomes can help promote hair growth and may treat hair loss.
January 2024 in “Journal der Deutschen Dermatologischen Gesellschaft” Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.
June 2023 in “IntechOpen eBooks” Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
103 citations,
December 2021 in “Journal of biological rhythms” Shift work disrupts the body's natural clock, leading to health problems.
10 citations,
July 2022 in “Dermatology and Therapy” Melasma's causes include genetics, sun exposure, hormones, and oxidative stress, and understanding these can help create better treatments.
8 citations,
April 2016 in “Experimental dermatology” B6.Cg-Tyr c−2J Hr hr /J mice have a stronger delayed sunburn reaction and are good for UV research.
August 2024 in “Stem Cell Research & Therapy” New regenerative therapies show promise for treating hair loss.
1 citations,
January 2018 in “Indian journal of dermatopathology and diagnostic dermatology” Trichoscopy helps diagnose and monitor hair and scalp problems without needing many biopsies.