50 citations
,
October 2011 in “Archives of Biochemistry and Biophysics” This study found that while calcium can substitute for the Vitamin D receptor in maintaining epidermal keratinocyte differentiation, it cannot compensate for hair follicle dysfunction caused by the absence of the receptor.
January 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that rhamnose can restore hair-inducing gene expression in dermal papilla cells and accelerate hair follicle regeneration by promoting the hair cycle into the anagen phase, suggesting its potential therapeutic application for alopecia treatment.
January 2023 in “Indian dermatology online journal” This case report describes a novel NECTIN4 gene mutation linked to ED-syndactyly syndrome 1 in a young girl, contributing to the understanding of this rare ectodermal dysplasia.
September 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that lymphatic vessels play a crucial role in hair follicle growth and regeneration in mice by connecting hair follicles and expanding during stem cell activation.
September 2020 in “Research Square (Research Square)” This study reported the expression patterns and potential functions of long non-coding RNAs in the hair follicle cycle of yak, with insights into their sequence conservation between yak and cashmere goat.
31 citations
,
April 2016 in “Nature communications” This study found that in adult mouse skin, reduced levels of histone H3 K4/K9/K27me3 during hair follicle stem cell quiescence are linked to proper tissue homeostasis.
26 citations
,
August 2019 in “Stem Cell Research & Therapy” This study found that PBX1 enhances the proliferation and reprogramming of hair follicle mesenchymal stem cells by activating the AKT/GSK3β signaling pathway, promoting NANOG expression, and inhibiting apoptosis.
January 2014 in “Journal of Investigative Dermatology” Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.
85 citations
,
January 2018 in “Cell stem cell” This study found that synchronized signals in the microenvironment regulate stem cell lineage choices in hair follicles by influencing chromatin dynamics during regeneration.
March 2016 in “Experimental Dermatology” This study reported that EGFR activation leads to suppression of Stathmin, which may promote synchronized entry into catagen in hair follicles, highlighting potential mechanisms involving EGFR in hair cycle transitions.
20 citations
,
July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
7 citations
,
January 2024 in “Cancer Research Communications” This study found that TAp63 and ΔNp63 isoforms in the p63 family interact with different transcription factors to regulate distinct transcriptional programs, affecting various biological functions like metabolic pathways, oxidative stress response, and epithelial morphogenesis in mouse epidermal cells.
1 citations
,
December 2012 in “Journal of Dermatological Science” FGF18 controls hair growth rest phase.
July 2023 in “Biomolecules” In this review, the authors discussed how the circadian clock influences hair follicle regeneration by regulating metabolism, suggesting potential new targets for hair loss treatments.
1 citations
,
February 2025 in “International Journal of Molecular Sciences” This study found that supplementing Liaoning cashmere goats with HMBi increased cashmere length while decreasing its diameter, attributed to changes in Met-related metabolites and elevated expression of genes related to the Met cycle and cell differentiation pathways such as Wnt and MAPK.
56 citations
,
February 2012 in “Cell Cycle” This review discusses the role of miRNA/mRNA regulatory networks in skin development, epidermal homeostasis, and tissue remodeling, and suggests potential for miRNA-based therapies in treating skin conditions, but reports no new clinical results.
3 citations
,
June 2013 in “Genes & development” In their research, Yucel and colleagues found that CaV1.2 is expressed in hair follicle stem cells, facilitating anagen re-entry in a way not dependent on calcium flux.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
4 citations
,
May 2025 in “Cells” This study found that miR-370-3p targets SMAD4 to inhibit cell proliferation, promote apoptosis, and affect the cell cycle in follicular papilla cells, demonstrating differences in their expression in sheep tissues, which may impact hair follicle development.
7 citations
,
January 2021 in “Evidence-based complementary and alternative medicine” This study suggests that porphyra-334 may have antiaging properties, promoting collagen synthesis, improving periorbital wrinkles, and supporting hair follicle growth through gene regulation.
1 citations
,
January 2023 in “Life sciences” This study demonstrated that elevated GABA levels can worsen stress-induced hair growth inhibition in mice, while GABAA antagonists like ginkgolide A may help alleviate these effects.
June 2024 in “Research Square (Research Square)” This study identified a network of interactions between miRNAs and mRNAs that involve key signaling pathways, suggesting new insights into the mechanisms behind androgenetic alopecia.
71 citations
,
November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This review discusses the role of Edar signaling in hair follicle development and cycling, emphasizing its impact on cell fate, differentiation, and interactions with other pathways, but reports no new results.
January 2026 in “Communications Biology” This study constructed a single-cell atlas of hair follicle cells from yaks and taurine cattle, revealing that differences in WNT signaling within dermal papilla cells may be key to the yak's adaptation to cold environments on the Qinghai-Tibet Plateau.
22 citations
,
April 2017 in “Journal of Investigative Dermatology” This review highlights recent advances in understanding how non-coding RNAs, particularly miRNAs and lncRNAs, regulate skin development and homeostasis, but reports no new clinical results.
18 citations
,
April 2010 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This research suggests that the vitamin D receptor may regulate hair follicle cycling and provide genoprotection against skin carcinogenesis through a mechanism independent of 1,25-dihydroxyvitamin D3, based on evidence from mouse models.
15 citations
,
April 2019 in “Journal of Cellular Biochemistry” This study identified specific miRNAs that are potentially linked to severe active alopecia areata, suggesting they could be targets for future treatment development.
12 citations
,
July 2021 in “Scientific Reports” This study found that exogenous glutamic acid can promote hair growth and keratinocyte proliferation, suggesting a novel signalling pathway in the skin.
11 citations
,
May 2023 in “Proceedings of the National Academy of Sciences” This study found that hair follicle stem cells are stiff with high actomyosin contractility, while hair germ progenitors are soft and enlarge during quiescence, influencing hair regeneration; inducing miR-205 reduces contractility and activates regeneration in mice.
6 citations
,
December 2017 in “Molecular Medicine Reports” This study found that Wnt5a expression may suppress cell differentiation and induce an inflammatory response in HaCaT keratinocytes, which could be relevant to psoriasis development.