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September 2007 in “BMC developmental biology” Neuregulin3 affects cell development in the skin and mammary glands.
33 citations,
June 2020 in “Journal of Clinical Investigation” Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.
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October 2019 in “Journal of lasers in medical sciences” CO2 laser treatment for aging skin significantly changes immune system-related genes.
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July 2009 in “Mutation research” N-acetyl-L-cysteine (NAC) can prevent DNA damage and protect cells from harm.
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December 2022 in “Biomolecules & therapeutics” Minoxidil may help reduce aging effects in brain cells.
55 citations,
May 2010 in “Cancer and Metastasis Reviews” TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.
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July 2017 in “European Journal of Dermatology” Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.
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191 citations,
September 2018 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.
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75 citations,
November 2018 in “Biochemical pharmacology” Targeting the skin's endocannabinoid system could help treat skin disorders.
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January 2019 in “Nature communications” Polyamines help fix DNA damage accurately in cells.
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January 2016 in “PubMed” Understanding how EDC genes are regulated can help develop better drugs for skin diseases.
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January 2000 in “Journal of Cutaneous Pathology” Short telomeres contribute to aging and cancer, and while telomerase can delay aging, it may also promote cancer.
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May 2010 in “Gastroenterology” Targeting colon cancer stem cells might lead to better treatment results.
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January 2018 in “Journal of Clinical Investigation” Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
232 citations,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.
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January 2014 in “International journal of reproductive medicine” Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.
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August 2019 in “Cells” The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.
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February 2015 in “Neuro-Oncology” Alisertib was found to be an effective and tolerable treatment for children with recurrent brain tumors.
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February 2011 in “Diabetes” People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.
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June 2016 in “Reviews in endocrine and metabolic disorders” Hidradenitis suppurativa may be related to hormones and patients often have metabolic disorders; more research is needed to understand this connection.
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October 2017 in “Biomolecules” Some growth factors, while important for normal body functions, can cause diseases when not regulated properly.
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May 2012 in “PloS one” Low ERCC3 gene activity is linked to non-pigmented hair growth.
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